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Forward viewing US endoscope versus standard oblique viewing US endoscope in the performance of EUS-guided fine needle aspiration of solid lesions of the gastrointestinal tract and of adjacent organs: A prospective randomized controlled study

The primary aim of the study is to compare the performance of the standard oblique-viewing US endoscope versus a prototype forward viewing ultrasonic endoscope for EUS-FNA of solid lesions of the GI tract and of adjacent organs.

Effect of deep neuromuscular block and variations in arterial PCO2 on the surgical rating scale, extubation conditions and postoperative conditions following reversal with sugammadex

To assess whether the implementation of a deep neuromuscular block (NMB) (PTC 1-2) combined with induction of relative hypocapnia creates optimal surgical conditions as measured by the surgeon (using the 5-point Leiden surgical rating scale) versus…

The Effect of Prehydration on the Pharmacokinetics of Low-dose Cisplatin

To determine if there is a difference in the pharmacokinetics of low-dose cisplatin with and without prehydration.

A Randomized, Double-blind Study To Evaluate the Efficacy and
Safety of Cabozantinib (XL184) at 60 mg/Day Compared to
140 mg/Day in Progressive, Metastatic Medullary Thyroid
Cancer Patients

The objective of this study is to evaluate the efficacy of oral cabozantinib at adaily dose of 60 mg compared with 140 mg in subjects with progressive,metastatic MTC.

An open label, multi-center roll-over study to assess long-term safety in patients who are ongoing or have completed a prior global Novartis or GSK sponsored Tafinlar (dabrafenib) and/or Mekinist (trametinib) study and are judged by the investigator to benefit from continued treatment

This study has been transitioned to CTIS with ID 2023-509318-13-00 check the CTIS register for the current data. This is an open-label, multi-center, roll-over study designed to provide continued access to subjects who have previously participated…

An open label, multi-center roll-over study to assess long-term effect in pediatric patients treated with Tafinlar (dabrafenib) and/or Mekinist (trametinib)

This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…

Microdosing as a tool to individualize docetaxel dosing: development of a limited sampling model

The primary objective of this study is to establish the relationship between microdose and therapeutic dose docetaxel pharmacokinetics. Our secondary objective is to develop a limited sampling model of microdose docetaxel pharmacokinetics to predict…

Cisplatin pharmacokinetics and skeletal muscle mass in patients with head and neck cancer: is cisplatin overdosed in patients with low skeletal muscle mass?

With this prospective study, we aim to investigate the relationship between skeletal muscle mass and cisplatin plasma pharmacokinetics in HNSCC patients treated with conventional primary and postoperative CRT with cisplatin. It is designed to be a…

Prospective monitoring of immune response following COVID-19 vaccination in children with cancer

PRIMARY OBJECTIVE: -To assess the antibody response after mRNA (Pfizer, Moderna) SARS-CoV-2 vaccination in children with cancerSECONDARY OBJECTIVES:To assess in children with cancer after SARS-CoV 2 vaccination:- durability of the antibody response…

Effect of a bundle of non-pharmacological interventions on the stress response to surgery

To assess the effect of a bundle of non-pharmacological interventions implemented in the post-anesthesia care unit on the total serum cortisol levels after intermediate and major surgery.

Low dose cisplatin weekly versus high dose cisplatin every three weeks in primary chemoradiation in sarcopenic head and neck cancer patients.

This study has been transitioned to CTIS with ID 2024-514919-10-00 check the CTIS register for the current data. To investigate if the use of weekly low dose cisplatin increases compliance to the planned chemotherapy scheme in LA-HNSCC patients with…

Microsampling to facilitate drug monitoring of oncolytics

The primary objective is to perform a clinical validation of the analytical method for dried blood spot microsampling of cabozantinib, pazopanib, sunitinib, Lenvatinib, nivolumab, ipilimumab, pembrolizumab, atezolizumab or bevacizumab. The secondary…