17 results
The study is divided in two parts. In the first part, we will study our hypothesis that the biological activity of antiangiogenic therapy is partly mediated by inhibition of platelets. We will study whether antiangiogenic agents inhibit the…
Evaluation and comparison of sentinel node biopsy (SNB) and ultrasound guided fine needle aspiration cytology (USgFNAC) in the management of the clinically negative neck in patients planned for transoral excision of oral and oropharyngeal squamous…
Primary objective is:To determine whether a single subcutaneous injection of G-CSF induces an immediate (within six hours) release of bone marrow progenitor cells in healthy volunteers.
Primary:To identify the recommended dose of sorafenib and of sirolimus for combination therapy in subsequent phase II trials Secondary:1. to determine the safety profile of the combination therapy of sorafenib with sirolimus.2. to determine, if…
This study has two primary objectives:To determine the effect of taxane therapy on the release of bone marrow derived endothelial progenitor cells.To study the effect of bevacizumab on taxane induced release of bone marrow derived endothelial…
AimThe aim of this study is to determine if WMFA measured by DTI at 3T MRI in cancer survivors is a suitable biomarker in children between 8 -16 years of age for treatment induced neurotoxicity and related neurocognitive deficits.
To evaluate the efficacy of AD 923 in comparison to MSIR in the management of breakthrough pain in subjects with malignicies who are taking a stable dose of background opioids.
To determine the diagnostic accuracy of FDG-PET-CT (pre-treatment and in the early phase of treatment) in the prediction of local control after primary radiotherapy with or without chemotherapy for functionally inoperable HNSCC.
To invetiate the:toxicity and the maximum tolerated dose.To determine the pharmacokinetic (PK) profile of JNJ-38877605 and its N-desmethyl metabolite,JNJ-40434654 and investigate the potential impact of food on the PK profile.To explore…
1. To develop and validate an optimal tracer kinetic model for quantitative analysis of [11C]docetaxel PET studies 2. To study the metabolism of [11C]docetaxel, to compare venous versus arterial sampling and to compare the use of an on-line…
Primary:To determine the effects of multiple-dose ketoconazole (Keto) on the pharmacokinetics of single-dose oral LBH589 in patients with advanced solid tumors.Secondary:In cancer patients with advanced solid tumors:* To assess the pharmacokinetic…
To obtain more information about the efficacy and tolerability of AD 923 in long-term management of breakthrough pain in subjects with malignicies who are taking a stable dose of background opioids and receive therapy for BTP.
The primary goal is to find out whether or not you can reach with the new cooling liquid in the Paxman cooler, and probably with air cooling, a ±5°C lower temperature of the scalp skin.The secundary goal is to find out how a possibly reached lower…
primary • To determinne the safety and tolerability of sorafenib when administered in combination with gemcitabine and carboplatin.• To determine the maximal tolerated dose (MTD), dose limiting toxicity (DLT) and optimal treatment schedule of…
To study the presence, number, type and specificity of tumour-specific immune response in the peripheral blood, tumour-draining lymph nodes and the tumour of patients with different types of HNSCC at different time-points during their normal…
To assess the response rate to the combination of gemcitabin plus oxlaiplatin in 5 different strata of relapsed/refractory pediatric solid tumors, in whom standard treatment has failed. Secondary objectives are the safety, the duration of response,…
Primary objective· • To investigate the safety and tolerability and establish either the dose of KU-0059436 which causes inhibition of PARP in combination with an active dose of carboplatin or the maximum tolerated dose (MTD) of KU-0059436 in…