25 results
Primary objective- To determine safety and tolerability of a single dose of cRGD-ZW800-1 in healthy volunteers.Secondary objectives- To determine the pharmacokinetics of a single dose of cRGD-ZW800-1 by measuring the fluorescence of blood and urine…
The UPGRADE-RT trial will investigate whether de-escalation of the elective radiation dose and introduction of an intermediate dose-level in the treatment of head and neck cancer will results in less radiation sequelae and improved quality of life…
2 Objectives2.1 Primary objective •To evaluate FAZA-PET/CT as a prognostic factor of the loco-regional control rate at 2 years in HNSCC patients receiving chemo-radiotherapy ± nimorazole.•Time to locoregional recurrence is counted from the day of…
Concluding, the aim of current study is to show feasibility of the MaMaLoc technology for surgical localization of clinically occult melanoma lesions, as well as to show feasibility of the MaMaLoc technology for lymph node detection, both in the…
The purpose of the study is to investigate to what extent SNDX-6352 is tolerated.It will also be investigated how quickly and to what extent SNDX-6352 is absorbed and eliminated from the body (pharmacokinetics). In addition, also the…
The study will be performed in 3 groups, Group 1, 2 and 3. Group 1 will be performed in 12 healthy non smoking male volunteers. Group 2 will be performed in 12 healthy non smoking male volunteers and Group 3 will be performed in 14 healthy smoking…
Primary objectives: To examine the ability of functional imaging signal changes over the course of treatment to distinguish patients with and without local recurrenceSecundary objectives:To examine the correlation between the different imaging…
Achieving an improvement on quality of life and a positive effect on pain, nausea, fatigue, sleeping disorders, mood and experience of stress by offering complementairy care.
Primary: To characterize safety and tolerability of LTT462 and identify a recommended dose and regimen for future studies in adult patients with advanced solid tumors harboring MAPK pathway alterations. Secondary: Preliminary anti-tumor activity,…
To determine the prognostic value of diffusion-weighted MRI and circulating tumor DNA (ctDNA) performed pre-treatment and during treatment in predicting the locoregional response to (chemo)radiation for HNSCC.
To compare the volume of the tumour as determined using DW-MRI images of laryngeal and hypopharyngeal tumours with that of the actual tumour as determined using histopathology after laryngectomy. Further, histopathology will be used to determine the…
To assess the safety of cisplatin doublets with hypofractionated radiotherapy (24 x2.75Gy).
This study has been transitioned to CTIS with ID 2023-504880-18-00 check the CTIS register for the current data. Primary• To determine the RP2D of crizotinib in combination with temsirolimus • To determine the safety and preliminary activity of…
To assess the effect of MEDI4736 in combination with olaparib±bevacizumab in patients with selected advanced solid tumors.To assess the safety and tolerability of MEDI4736 in combination with olaparib (±bevacizumab) in patients with selected…
To map the pharmacokinetics of monoclonal antibodies.
This study has been transitioned to CTIS with ID 2022-501253-37-00 check the CTIS register for the current data. The primary efficacy objective of this trial is to evaluate the anti-tumor activity of pembrolizumab in subjects with any of a *basket*…
The primary objective of this study is to establish the relationship between microdose and therapeutic dose docetaxel pharmacokinetics. Our secondary objective is to develop a limited sampling model of microdose docetaxel pharmacokinetics to predict…
The primary objective of the present study is to evaluate the accuracy of platelet RNA profiling for occult cancer detection in patients of 40 years or older with a first episode of unprovoked VTE, in an investigator-initiated, multinational,…
The main purpose is to establish the intraoperative use of cetuximab-IRDye800CW as a reliable marker for residual tumor in resection margins after surgical removal of HNSCC. The objective is to establish the positive predictive value of cetuximab-…
This drug-drug interaction (DDI) study is being conducted to determine if there is a pharmacokinetic (PK) interaction between trametinib and the components of combination oral contraceptives (OCs), norethindrone (NE) and ethinyl estradiol (EE).…