280 results
Primary objective; Ex vivo charting of T cell reactivity directed against the tumour antigen survivin in peripheral blood of HNSCC patients. Secondary objective; Ex vivo charting of T cell reactivity against tumour antigens other than survivin.…
Primary objective:•To compare the pharmacokinetic (PK) profiles of gemcitabine-5*-elaidate (parent compound) of two formulations of CO-1.01 in order to investigate whether the confidence interval (CI) for the ratio of the AUC0-* of the two…
Primary: • To determine the safety and feasibility of PK guided dosing of sunitinib Secondary:• To determine the objective response rate (according RECIST 1.1)• To determine the time to tumor progression and progression free survival• To validate…
Primary:To assess the effect of various degrees of impairment in hepatic function as measured by NCICTEPcriteria, on the pharmacokinetics of panobinostat.Secondary:To assess the effect of various degrees of hepatic functions on the safety of…
To improve normalcy of food intake (food quantity and quality, decrease use of tube feeding/ nutritional supplements) in patients with head and neck cancer with pre-, per- and post treatment radiotherapy due to individually tailored swallowing…
Primary: To observe the correlation between ABCB1 polymorphisms in Exons 13, 22 and 27 and the clearance of sunitinib at steady state. Secondary: - To determine whether ABCB1 genotype correlates with toxicity-adjusted dose of sunitinib - To…
- The primary objective is to determine the dose limiting toxicity and the maximum tolerated dose and recommended dose of the combination of temsirolimus weekly and nelfinavir orally BID to patients with advanced solid tumors.- Secondary objective…
Primary:To identify the recommended dose of sorafenib and of sirolimus for combination therapy in subsequent phase II trials Secondary:1. to determine the safety profile of the combination therapy of sorafenib with sirolimus.2. to determine, if…
This study has two primary objectives:To determine the effect of taxane therapy on the release of bone marrow derived endothelial progenitor cells.To study the effect of bevacizumab on taxane induced release of bone marrow derived endothelial…
To evaluate the efficacy of AD 923 in comparison to MSIR in the management of breakthrough pain in subjects with malignicies who are taking a stable dose of background opioids.
• To determine pharmacokinetic interactions between St. John*s wort and docetaxel and between echinacea and docetaxel in patients with cancer.• To determine the safety of the use of St. John*s wort or echinacea in combination with docetaxel.• To…
The aim of the study is to obtain a profile of the circadian rhythm in blood pressure, in a representative population of cancer patients, thereby providing a base signal for the pharmacokinetic-pharmacodynamic model for hypertension associated with…
To invetiate the:toxicity and the maximum tolerated dose.To determine the pharmacokinetic (PK) profile of JNJ-38877605 and its N-desmethyl metabolite,JNJ-40434654 and investigate the potential impact of food on the PK profile.To explore…
Primary:To determine the effects of multiple-dose ketoconazole (Keto) on the pharmacokinetics of single-dose oral LBH589 in patients with advanced solid tumors.Secondary:In cancer patients with advanced solid tumors:* To assess the pharmacokinetic…
The primary objective is to select one of two platinum strategies to be used in this regimen for use as experimental arm in Phase III. This is a screening feasibility study addressing purely investigational approaches.
Compare Progression Free Survival (PFS) for brivanib versus placebo in subjects with advanced solid tumors with FGF-2 over-expression and who have obtained stable disease after 12 weeks of treatment with brivanib separately for each tumor.
To obtain more information about the efficacy and tolerability of AD 923 in long-term management of breakthrough pain in subjects with malignicies who are taking a stable dose of background opioids and receive therapy for BTP.
The primary goal is to find out whether or not you can reach with the new cooling liquid in the Paxman cooler, and probably with air cooling, a ±5°C lower temperature of the scalp skin.The secundary goal is to find out how a possibly reached lower…
primary • To determinne the safety and tolerability of sorafenib when administered in combination with gemcitabine and carboplatin.• To determine the maximal tolerated dose (MTD), dose limiting toxicity (DLT) and optimal treatment schedule of…
Objective: The primary objective of this study is to show that early detection of geriatric patients at risk of preventable functional decline following a surgical procedure under general anesthesia for a solid tumor, combined with a geriatric…