280 results
The aim of the study is to investigate the feasibility, safety, toxicity, quality of life (QoL), and regional control of unilateral ENI using SNM with SPECT/CT to select patients with unilateral drainage in lateralized HNSCC treated with primary…
The primary objective of this study is to proof the principle of imaging a tumour in-vivo, with Cerenkov radiation.Furthermore we want to determine the difficulties and limiting factors for in-vivo CLI. Determine the SNR (Signal to Noise) and the…
The purpose of this study is to compare the technical success rates, scores on the visual analogue scale (VAS) and complications after retrograde and antegrade double J catheter insertion in patients with extrinsic urinary tract obstruction.
Primary objectives: we aim to investigate the feasibility of NK cell immunotherapy by evaluating the expression of activating and inhibitory NK cell receptor ligands on primary tumor cells. secondary objectives: we aim to evaluate the cytotoxic…
Primary Objective: - To study the effect of mucositis on the absorption of sublingually delivered fentanyl (Abstral®) in head and neck cancer patients treated with chemoradiotherapy. Secundary Objective:- To study the effect of xerostomia on the…
Primary Objective: Compare achievement of glycemic control in SSI therapy and NPH insulinGlycemic control is defined as the proportion of glucose measurements within target range (Fasting target glucose 3.9 * 7.8 mmol/l. Random target glucose 3.9-10…
The present study is aimed at identifying the specific routes of plitidepsin excretion and elimination following its administration to patients with advanced tumors. Also, the study design may allow the identification and quantification, if possible…
To assess safety, tolerability and pharmacokinetics of a single subcutaneous administration of HPV-NIRD1.
To perform sensory testing in patients who have undergone a cervical percutaneous cordotomy. The sensory testing include 'quantitative sensory testing' according to the *the German Research Network on Neuropathic Pain* protocol and a *…
Concluding, the aim of current study is to show feasibility of the MaMaLoc technology for surgical localization of clinically occult melanoma lesions, as well as to show feasibility of the MaMaLoc technology for lymph node detection, both in the…
Objectives:Primary:• To determine the absolute bioavailability of niraparib by using an intravenous (IV) niraparibmicrodose of 100 µg (containing approximately 1 µCi of [14C]-niraparib) in subjects with cancer.Secondary:• To characterize the…
To determine if there is a difference in the pharmacokinetics of low-dose cisplatin with and without prehydration.
The purpose of the study is to investigate to what extent SNDX-6352 is tolerated.It will also be investigated how quickly and to what extent SNDX-6352 is absorbed and eliminated from the body (pharmacokinetics). In addition, also the…
The study will be performed in 3 groups, Group 1, 2 and 3. Group 1 will be performed in 12 healthy non smoking male volunteers. Group 2 will be performed in 12 healthy non smoking male volunteers and Group 3 will be performed in 14 healthy smoking…
Achieving an improvement on quality of life and a positive effect on pain, nausea, fatigue, sleeping disorders, mood and experience of stress by offering complementairy care.
The purpose of this study is to evaluate the safety and preliminary efficacy of avelumab in combination with M9241in subjects with metastatic or locally advanced unresectable solid tumors. This dose escalation study will establish a safe dose of…
To study the presence, number, type and specificity of tumour-specific immune response in the peripheral blood, tumour-draining lymph nodes and the tumour of patients with different types of HNSCC at different time-points during their normal…
This study has been transitioned to CTIS with ID 2023-509318-13-00 check the CTIS register for the current data. This is an open-label, multi-center, roll-over study designed to provide continued access to subjects who have previously participated…
The primary objective is comparison of the CYP3A4 activity in medically castrated patients with prostate cancer with the CYP3A4 activity of male patients with other types of solid tumours. To evaluate the CYP3A4 activity, the PK of the CYP3A4…
This study has been transitioned to CTIS with ID 2023-509276-42-00 check the CTIS register for the current data. Primary:To assess the long-term safety of treatment with dabrafenib, trametinib or the combination.Secondary:To assess the long-term…