197 results
The primary objective of this study is to obtain clinically characterized, whole blood specimens from subjects with a new or suspected diagnosis of cancer (cancer subjects) and from subjects who do not have a diagnosis of cancer (healthy) to develop…
The aim of this study is both a feasibility study to gain a comprehensive understanding of the feasibility, satisfaction and impact, and trends of the effects of a physical exercise and nutritional intervention in patients who will be treated by a…
Primary study objective The primary objective of this study is to determine the (cost-) effectiveness of tailored support for work- related problems of gastro intestinal (GI) cancer patients on return to work compared to GI cancer patients who…
The primary objective of the study is to compare the progression-free survival (PFS) of REGN2810 (cemiplimab) plus ipilimumab combination therapy (hereinafter referred to as REGN2810/ipi) and REGN2810 plus 2 cycles only of platinum-based doublet…
The purpose of the study is to investigate how quickly and to what extent 2 different production batches of alpelisib (FMI and FMIopt) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…
Since multiple dimensions (physical, emotional and cognitive) seem to be involved in the pathophysiology of fatigue, multidimensional approach to alleviate will probably have a synergistic effect. Previous studies supporting this assumption included…
The primary objective of this study is to assess presence, number, type, specificity and function of HPV-specific immune response in the peripheral blood, lesions/tumors and their draining lymph nodes of patients at different stages of HPV-induced…
The objective of this study is to identify genetic variations associated with clinical response and toxicity in non-small cell lung cancer patients (NSCLC) undergoing chemoradiation or chemotherapy with platinum agents (carboplatin, cisplatin). The…
The objective of this study is to investigate the safety and efficacy of pertuzumab in combination with standard therapy, trastuzumab and a taxane.
Phase Ib: To estimate the MTD and/or RP2D of INC280 in combination with buparlisib in patients with recurrent glioblastoma.Phase II: To estimate the anti-tumor activity of INC280 single agent and in combination with buparlisib in patients with…
To demonstrate a 25% increase of docetaxel in tumor tissue after intravenous with CriPec® docetaxel compared to Taxotere®. Additionally, systemic PK profile and adverse events will also be evaluated.
The aim of this study is to evaluate the changing over time of AA levels in plasma and in leukocytes before and during chemotherapy treatment for several different groups of patients and compare that to healthy controls.
Objective: This study will evaluate the effectiveness of IPAS, with and without additional support, for enhancing objectively measured PA levels. We expect that IPAS will increase levels of PA more than usual care (UC), with a larger expected effect…
Primary objective is to evaluate the area under the plasma concentration-time curve (AUC) of capecitabine alone, compared to capecitabine used with esomeprazole and compared to capacitabine used with esomeprazole and the acid beverage Coca-Cola in…
To demonstrate that a dose reduction of 20-33% of CYP3A4 metabolized tyrosine kinase inhibitors in patients expressing the CYP3A4*22 gene (rs35599367 C>T in intron 6) does not result in a lower exposure (Ctrough) than the wildtype group with…
To demonstrate that treatment with avelumab in combination with standard of care (SOC) CRT is superior to SOC CRT alone in prolonging progression-free survival (PFS) in front-line patients with high-risk (as defined in Inclusion Criterion 2),…
To assess the feasibility and efficacy of Carfilzomib in combination with Thalidomide and Dexamethasone in a phase II trial.