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The diagnostic potential of tumor derived extracellular vesicles (tdEVs) in plasma and urine of prostate cancer patients and healthy volunteers: pilot study.

Determination of the number of tdEVs in plasma and urine in PCa patients at different stages, together with appropriate controls. This will be determined by the use of different EV enumeration and molecular techniques. For comparison, some sample…

Safety, feasibility and cost-effectiveness of genotype-directed individualized dosing of fluoropyrimidines

The primary objective is to determine whether the rate of severe toxicity (CTC grade 3 to 5) associated with fluoropyrimidine treatment can be significantly diminished by individualized dosing of fluoropyrimidines based on upfront genotypic…

Obtaining and analyzing plasmasamples from patients with non small cell lung cancer, referred for radiation treatment and/or chemotherapy

The aim of this pilot study is to investigate the hypothesis that certain biomarkers of ICD that were identified in vitro or ex vivo are detectable in patient sera following radiotherapy and/or chemotherapy. Radiotherapy alone or concurrent…

Active and passive elasticity measurements of the tongue using in vivo measurement techniques

The primary objectives of this study are:* Analyse if shear wave ultrasound elastography with ElastQ and LASTIC are both feasible techniques to identify differences in tongue tissue elasticity and analyse if there is a correlation between both…

A Multi-Center InternatiONal Registry to Evaluate the Efficacy oF Imaging with Opto-acoustics to Diagnose BrEast CaNCEr

The objective of this post market surveillance registry is to assess whether the Imagio OA/US technology for the indication of breast mass/focal finding diagnosis provides performance characteristics that could be used for worldwide clinical…

Image guided surgery in sinonasal inverted papilloma by targeting vascular endothelial growth factor

The main objective is to study if the conjugate bevacizumab-IRDye800CW accumulates more in sinonasal inverted papilloma than in normal sinonasal mucosa, with a TBR of *2 as cutoff value.

Personalisation of a biomechanical tongue model for the prediction of treatment outcome.

The next step is to personalize the model and validate the model using different modalities. These modalities are grouped into four subprojects. Finally, the results of the subprojects will be integrated within the biomechanical model so that a…

Shear wave ultrasound elastography of the tongue * a feasibility study.

The primary objective of this study is to investigate how treatment affects tissue elasticity and to what extent those effects vary in patients. The secondary objective is to link elasticity to tongue muscle strength and to functional outcome.

Optimization of MR diffusion image quality and the use of low-b-values at intravoxel incoherent motion in head and neck

Primary objective: - Optimization of MR diffusion quality in head and neck squamous cell carcinoma by an extension of the scan protocol and a pillow filled with pineapple juice. Secundary objective:- To determine the most optimal amount and…

Tacrolimus monotherapy in immunologically low-risk kidney transplant recipients: a pilot randomized-controlled study.

The primary objective of the main non-inferiority study is to determine the safety of TACmono starting nine months after kidney transplantation in immunologically low-risk patients in terms of BPAR-rate 15 months after transplantation compared to…