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Effects of Dynasplint Trismus System® excercises compared to TheraBite® Jaw Motion Rehabilitation System* exercises on mouth opening in patients with trismus secondary to head and neck cancer; a randomized controlled trial.

To compare the effects of exercise therapy on mouth opening using the TheraBite and the DTS in a randomized controlled trial in head and neck cancer patients suffering from trismus.

A PHASE 1B/2 OPEN-LABEL STUDY TO EVALUATE SAFETY, CLINICAL ACTIVITY, PHARMACOKINETICS AND PHARMACODYNAMICS OF AVELUMAB* (MSB0010718C) IN COMBINATION WITH OTHER CANCER IMMUNOTHERAPIES IN PATIENTS WITH ADVANCED MALIGNANCIES

Primary Objectives* Phase 1b lead-in: To assess safety and tolerability of a single dose level of avelumab in combination withincreasing dose levels of other immune modulators in combination with a single doselevel of avelumab in patients with…

Effects of a short-term dietary restriction regimen in cancer patients receiving irinotecan.

Primary objective is to demonstrate a 25% reduction of the active irinotecan metabolite, SN38, in healthy liver tissue in patients with mCRC or other solid tumors as a result of preceding dietary restriction five days in advance. Secondary…

An international field study for the reliability and validity of the EORTC Sexual Health Questionnaire (EORTC SHQ-C22) for assessing sexual health in cancer patients.

The aim of this international field study is to test the scale structure, reliability, responsiveness to change and validity of the EORTC SHQ-C22 in patients with different cancer diagnoses, at different stages of disease, and with different…

A multicenter, open label, phase 1 dose escalation study to evaluate the pharmacokinetics, safety, and tolerability of INC280 tablet formulation with food in patients with cMET dysregulated advanced solid tumors

Primary: 1/ To determine the higher of the tolerated dose of INC280 tablets with food between 300 and 400 mg BID in patients with cMET dysregulated advanced solid tumors. 2/ To assess the PK of INC280 with food.Secondary: To assess the safety of…

Changes to the mitochondrial DNA in non-cancer cells induced by chemotherapy and the relation with fatigue in men with germ-cell cancer of the testis: a feasibility study.

In this pilot study, we want to investigate whether it is feasible to study the accumulation of changes in mtDNA in non-cancer cells as a possible explanation for the development of fatigue in patients treated with chemotherapy for metastatic…

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Multicenter Study of PEGylated Recombinant Human Hyaluronidase (PEGPH20) in Combination With nab-Paclitaxel Plus Gemcitabine Compared With Placebo Plus nab-Paclitaxel and Gemcitabine in Subjects with Hyaluronan-High Stage IV Previously Untreated Pancreatic Ductal Adenocarcinoma

Primary objective is: * To determine the overall survival (OS) benefit of PAG treatment, compared with AG treatment, in subjects with HA-high Stage IV previously untreated PDA.Secundary objectives are:* To determine the PFS benefit of PAG treatment…

The effect of colon cancer on muscle gene expression, body composition, muscle function, and muscle metabolism

Primary Objective: Main aim of the study is to investigate in detail the differences in gene expression, body composition, muscle function and muscle metabolism in colon cancer patients compared to controls. Secondary objectives:Secondary aim of the…

A randomized, double-blind, placebo-controlled, phase III study comparing the combination of PDR001, dabrafenib and trametinib versus placebo, dabrafenib and trametinib in previously untreated patients with unresectable or metastatic BRAF V600 mutant melanoma

* Safety Run inTo determine the recommended regimen of PDR001 in combination with dabrafenib and trametinib for the randomized part (part 3)* Biomarker cohortTo evaluate changes in the immune microenvironment and biomarker modulations upon treatment…

An exploratory tumor biopsy-driven study to understand the relationship between biomarkers and indicators of clinical response in immunomodulatory treatment naïve unresectable stage III/IV melanoma patients receiving REGN2810 (anti-PD-1)

The primary objective of the exploratory study is to characterize the types and dynamics of changes in the tumor microenvironment that occur following programmed-death-1 (PD-1) receptor blockade with REGN2810 and to assess their relationship to the…

An open-label cross-over proof of concept study to investigate the intratumoral pharmacokinetics of CriPec® docetaxel versus Taxotere® (the CRITAX study)

To demonstrate a 25% increase of docetaxel in tumor tissue after intravenous with CriPec® docetaxel compared to Taxotere®. Additionally, systemic PK profile and adverse events will also be evaluated.

Development of a GMP protocol for personalized adoptive T-cell therapy

The primary objective is to develop a cell therapy production protocol in line with Good Manufacturing Practice (GMP) regulations by which an autologous T-cell product is generated towards tumor-specific neoantigens. The secondary objective is to…