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Clinimetric properties of measurements on neck and shoulder function, strength, exercise capacity, level of physical mobility and maximal opening of the mouth in head and neck cancer survivors

The goal of this study is to be able to perform reliable measurements on AROM of neck and shoulders , exercise capacity, strength, MMO and functional mobility to evaluate the effectiveness rehabilitation programs in head and neck cancer survivors.

The efficacy of Sonographic and biological pleurodesis Indicators of Malignant Pleural Effusion (SIMPLE) - a randomised trial

This trial will prospectively test the use of ultrasound imaging and pleural fluid analysis in improving the management of patients with malignant pleural effusion.Primary objective: Establish if the use of TUS before and during the first 24-72…

A phase II, multicenter, randomized, two-arm study of capmatinib (INC280, an oral MET inhibitor) and spartalizumab (PDR001, a PD-1 inhibitor) combination therapy versus docetaxel in pretreated adult patient with EGFR wild-type, ALK rearrangement negative locally advanced/metastatic non-small cell lung cancer.

The aim of this prospective, multicentre randomized phase II study is to evaluate the safety and efficacy of the combination of capmatinib and spartalizumab in subjects with EGFR weight (for exon 19 deletions and exon 21 L858R substitution mutations…

A Phase 1b-2 study of Mitomycin-C / Capecitabine chemoradiotherapy combined with Ipilumimab and Nivolumab or Nivolumab monotherapy as bladder sparing curative treatment for muscle Invasive bladder Cancer: the CRIMI study.

This study has been transitioned to CTIS with ID 2023-509460-19-00 check the CTIS register for the current data. *In the phase Ib study: to assess the feasibility and safety of the addition of nivolumab and/or ipilimumab to MMC/capecitabine…

Real time Molecular Fluorescence and Narrow Band Imaging for detection of the Primary Cancer Lesion in Patients with a Metastatis of Unknown Primary Tumor in the Head and Neck

This study has been transitioned to CTIS with ID 2024-513897-23-00 check the CTIS register for the current data. The main objective of this study is to evaluate the use of molecular fluorescence imaging using cetuximab-IRDye800CW in the detection of…

Quantitative MR imaging in locally advanced cervical cancer

Primary: To evaluate the sensitivity and specificity of dynamic contrast enhanced (DCE-MRI) to identify patients who have increased risk of disease recurrence (local, nodal, systemic) after radio-chemotherapy of cervix cancer.Secondary: To apply…

Assessing optimal treatment settings for the ablation of locally advanced pancreatic cancer with CT-guided percutaneous irreversible electroporation: a randomized feasibility study.

The objective of this study is to compare two IRE protocols for the treatment of LAPC that are currently being used in clinical treatment, to allow for the determination (based on survival and co-morbidity) of the optimal treatment protocol for IRE…

The use of SPEctroscopy during Endoscopy for Detection of PANcreatic Cancer

Primary Objective: - The ability of SFR spectroscopy incorporated in EUS-FNA procedure in distinguishing benign and malignant pancreatic tissue by measuring wavelength dependent optical characteristics over a broad wavelength range (400-1000 nm).…

A Phase 1 Drug-Drug Interaction Study Between Brigatinib and the CYP3A Substrate Midazolam in Patients With ALK-Positive or ROS1-Positive Solid Tumors

Primary Objective: To characterize the effect of repeat-dose administration of brigatinib 180 mg QD on the single-dose PK of midazolam.Other Objectives:Safety: To assess the safety and tolerability of brigatinib in patients with ALK-positive or ROS1…

ARTIS: Activating Relatives To get Involved in care after Surgery

To evaluate whether a family involvement program comprising a set of evidence-based basic care activities reduces the number of unplanned readmissions and postoperative complications after major abdominal surgery.

Intervention to support return to work in sick-listed employees with cancer: a randomized controlled trial.

The primary objective of this research is to obtain insight in de (cost-)efficiency of a multidisciplinary intervention focused on the improvement of return to work after sick leave of employees with cancer. Specific research questions are:- Does…

A Randomized, Phase 3, Open-Label Study of Combinations of REGN2810 (Anti-PD-1 Antibody), Platinum based Doublet Chemotherapy, and Ipilimumab (Anti-CTLA-4 Antibody) Versus Pembrolizumab Monotherapy in First-Line Treatment of Patients With Advanced or Metastatic Non-Small Cell Lung Cancer With Tumors Expressing PD-L1 >=50%

The primary objective of the study is to compare the progression-free survival (PFS) of REGN2810 (cemiplimab) plus ipilimumab combination therapy (hereinafter referred to as REGN2810/ipi) and REGN2810 plus 2 cycles only of platinum-based doublet…

A single-center, randomized, open-label, two cohort, two-period crossover study to investigate the bioequivalence of alpelisib optimized final market image formulation (FMIopt) and the final market image (FMI) tablet formulation in healthy volunteers in the fasted and fed state

The purpose of the study is to investigate how quickly and to what extent 2 different production batches of alpelisib (FMI and FMIopt) are absorbed and eliminated from the body (this is called pharmacokinetics). In this study it is investigated…

Cancer rehabilitation for Hepato-Pancreato-Biliary cancer patients undergoing surgical treatment

Since multiple dimensions (physical, emotional and cognitive) seem to be involved in the pathophysiology of fatigue, multidimensional approach to alleviate will probably have a synergistic effect. Previous studies supporting this assumption included…

Endothelial function after anthracycline treatment.

The primary objective is to explore endothelial function in patients before and after treatment with anthracyclines.

Deep Sound Wave Therapy for the prevention of neuropathy in the treatment of colorectal and breast cancer with chemotherapy:
a pilot / feasibility study '

The aim of this pilot is to get an impression of the feasibility and added value of administering deep sound waves to the body during (neo) adjuvant chemotherapy. In addition, we want to gain insight into whether or not complete completion of a…

The diagnostic potential of tumor derived extracellular vesicles (tdEVs) in plasma and urine of prostate cancer patients and healthy volunteers: pilot study.

Determination of the number of tdEVs in plasma and urine in PCa patients at different stages, together with appropriate controls. This will be determined by the use of different EV enumeration and molecular techniques. For comparison, some sample…

Active and passive elasticity measurements of the tongue using in vivo measurement techniques

The primary objectives of this study are:* Analyse if shear wave ultrasound elastography with ElastQ and LASTIC are both feasible techniques to identify differences in tongue tissue elasticity and analyse if there is a correlation between both…

A Multi-Center InternatiONal Registry to Evaluate the Efficacy oF Imaging with Opto-acoustics to Diagnose BrEast CaNCEr

The objective of this post market surveillance registry is to assess whether the Imagio OA/US technology for the indication of breast mass/focal finding diagnosis provides performance characteristics that could be used for worldwide clinical…

Image guided surgery in sinonasal inverted papilloma by targeting vascular endothelial growth factor

The main objective is to study if the conjugate bevacizumab-IRDye800CW accumulates more in sinonasal inverted papilloma than in normal sinonasal mucosa, with a TBR of *2 as cutoff value.