18 results
Primary objective:To investigate in Adolescent and Young Adult (AYA) Head and Neck Cancer (HNC) survivors treated with unilateral radiotherapy 5-10 years before, the long-term vascular complications in terms of carotid wall changes (ultrasonography…
The objective of this study is to develop a method whereby reliably can be determined if there are microscopic metastases in the neck lymph nodes of H&N cancer patients. In those patients with "clean" nodes the irradiation can be…
This study has been transitioned to CTIS with ID 2024-516922-70-00 check the CTIS register for the current data. Phase I• Primary objectives:o To study the safety and feasibility of AT with autologous MC2 TCR T cells, combined with epigenetic drug…
We aim to identify immunological parameters during (immune)therapy. We will study the effect of (immune)therapy on generic immune mediators and more specifically for NK cell, T effector and Treg cell functionality. Furthermore, we will explore DNX…
We want to investigate what happens to the immune cells during different types of radiotherapy (schedules). With this study, we want to take blood samples from patients during their standard radiotherapy for cancer and determine the effect on immune…
The purpose of the EFFECT study is to assess the effects of a structured and individualised 9-month exercise intervention in patients with metastatic breast cancer. We will look at the effects on fatigue, quality of life, and other disease and…
Primary:To determine the efficacy (as defined by progression-free survival [PFS]) of nirogacestat in adult participants with progressing DT/AF.Secondary:To evaluate the safety and tolerability of nirogacestat in adult participants with progressing…
The primary objective of this study is to obtain accurate data regarding physical activity and body weight loss over time in patients with cancer who are undergoing primary curative cancer treatment (chemotherapy or surgery) and relate this to…
The primary objectives are:- To evaluate the safety and tolerability of IT administration of CyPep-1 as monotherapy and in combination with pembrolizumab.- To identify the recommended phase II dose (RP2D) of CyPep-1 as monotherapy and in combination…
The primary aim of the study is to compare the effect of PRO symptom monitoring with standard care on QoL both during and up to 1 year after treatment. Secondary aims are studying the effect of PRO symptom monitoring compared to standard care on the…
The primary objective of this one-group pre-test post-test pilot study is to assess the feasibility of a home-based personalized prehabilitation program of approximately four weeks (usual care) in high-risk patients scheduled for elective colorectal…
The primary objective of this study is to determine the competence of a magnetic marker as a technique to localise non-palpable breast cancer, measured through retrieval rate using only the magnetic probe. The secondary objectives of this study are…
To determine whether the incidence of severe toxicity (defined as grade 3 to 5, grading according to the National Cancer Institute Common Terminology Criteria for Adverse Events, NCI CTC-AE version 5.0) associated with fluoropyrimidine treatment can…
Develop and evaluate the potential of TEPs and ctDNA as a novel liquid biomarker for early ovarium cancer diagnostics. And to evaluate the accuracy of ctNDA on response evaluation in patients with ovarian carcinoma.
To evaluate the safety and efficacy of 177Lu-PSMA RLT in patients with R/M ACC and SDC with PSMA ligand uptake.
The primary objective is to investigate if ADT can increase the uptake of 68Ga-PSMA in patients with R/M SDC.
Primary objective:To identify novel variants in the DPYD gene in non-Western patients that are related to the occurrence of severe (grade *3) toxicity upon treatment with fluoropyrimidines.Secondary objective:* To determine the influence of novel…
The aim of this study is to investigate the amount of clinically relevant SRML (defined in this study as *5% muscle loss within one week measured by the cross sectional area (CSA) of the different muscles) in patients after major abdominal surgery…