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A Phase 1 Open-label, Multicenter Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of HBM4003 in Subjects with Advanced Solid Tumors

Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…

The UMBRELLA Study - MRI protocol development for MRI for MR-guided radiotherapy on the MR-Linac

Goal of the UMBRELLA Study is the optimization of existing MRI protocols and processing techniques required for MRI guided radiation treatment on the Marlin system (MRI of the MR-Linac) and diagnostic MRI scanners in the radiology department needed…

The prognostic value of occult peritoneal tumor cells, detected by ddPCR for KRAS, in patients with (borderline) resectable pancreatic cancer

To add 36 benign control patients to the Expect study to investigate whether detection of a KRAS mutation by ddPCR in peritoneal fluid is truly specific for pancreatic cancer.

DAVINCY trial: optimal Duration of (fos)aprepitant prophylaxis for nausea and Vomiting INduced by ChemotherapY in children: a double-blind placebo-controlled crossover randomized phase III trial*

This study has been transitioned to CTIS with ID 2024-517846-32-00 check the CTIS register for the current data. To evaluate the effect of prolonged duration of (fos)aprepitant prophylaxis on the prevention of delayed CINV (complete remission in the…

A Randomized, Open-Label, Phase 3 Trial of Tisotumab Vedotin vs Investigator*s Choice Chemotherapy in Second- or Third-Line Recurrent or Metastatic Cervical Cancer

The purpose of this study is to demonstrate improvement in clinical efficacy of tisotumab vedotin compared to chemotherapy in participants with second- or third-line (2L-3L) cervical cancer (Overall Survival-OS)

A Phase 2 Multicenter Study of Autologous Tumor Infiltrating Lymphocytes (LN -145) in Patients with Metastatic Non-Small-Cell Lung Cancer

This study has been transitioned to CTIS with ID 2024-510778-26-00 check the CTIS register for the current data. Primary Objective:To evaluate the efficacy of LN-145 measured by objective response rate (ORR) usingResponse Evaluation Criteria in…

AntiBody response in Risk groups to COrona Vaccination treated in the Adrz hospital:

In the coming months, immunocompromised patients treated in our hospital will be requested to undergo vaccination if they comply with the National Institute for Public Health guidelines. For all subgroups, it is of utmost importance to assess the…

Vascular Signature Mapping of Brain Tumor Genotypes

The primary objective is to develop and clinically validate a fast multi-parametric MRI acquisition technique, for non-invasive and comprehensive characterization of the tumor*s vascularization, *vascular signature mapping*, at 3 Tesla (3T) and 7…

A Randomized Controlled Trial on Additional Treatment for Isolated Local Pancreatic Cancer Recurrence Using Stereotactic Body Radiation Therapy

To improve survival after recurrence in patients with isolated local PDAC recurrence using local ablative treatment with SBRT inaddition to standard of care.

A PHASE Ia/b, OPEN-LABEL, DOSE-ESCALATION STUDY OF THE SAFETY AND PHARMACOKINETICS OF RUNIMOTAMAB ADMINISTERED INTRAVENOUSLY AS A SINGLE AGENT AND IN COMBINATION WITH TRASTUZUAMB IN PATIENTS WITH LOCALLY ADVANCED OR METASTATIC HER2-EXPRESSING CANCERS

This study has been transitioned to CTIS with ID 2023-504491-15-00 check the CTIS register for the current data. • To evaluate the safety and tolerability of Runimotamab when administered as a single agent (Phase Ia) and in combination with…

The STELLAR trial: Fluorescence-guided surgery in laryngeal- and hypopharyngeal cancer: a feasibility trial

This study has been transitioned to CTIS with ID 2024-519750-36-00 check the CTIS register for the current data. The primary aim of this study is to determine the feasibility of using intraoperative fluorescence-imaging (FLI) to identify laryngeal…

Magnetic resonance imaging-guided focal laser ablation of prostate cancer

Primary objectiveThe primary objective for this phase IIa study is to investigate the feasibility, usability and safety of CLS MR-guided FLA in the treatment of prostate cancer.Secondary objectiveTo assess tumor response and functional outcomes

Effect of PROtons versus photons on IMMUNOlogical function in head and neck cancer (PRO-IMMUNO): a pilot study.

We aim to establish the difference in immunological function of HNSCC patients undergoing (chemo)radiation with protons versus photons. These preliminary data are required to follow-up with larger studies to compare the effect of proton (chemo)radio…

EPIK-P2: A Phase II double-blind study with an upfront, 16-week randomized, placebo-controlled period, to assess the efficacy, safety and pharmacokinetics of alpelisib (BYL719) in pediatric and adult patients with PIK3CA-related overgrowth spectrum (PROS)

This study has been transitioned to CTIS with ID 2023-508530-34-00 check the CTIS register for the current data. Primary objective:* To demonstrate the efficacy of alpelisib as measured by the proportion of participants randomized to alpelisib with…

Administration of immune checkpoint inhibitors through an elastomeric pump. A patient preference study and cost analysis.

The primary objective of this study is to evaluate the patient preference for either ICI-B or ICI-P. Secondary objectives are: to assess patient satisfaction with ICI-B and ICI-P, to establish the safety of ICI-B and ICI-P to establish the…

A single-center, open-label study to evaluate the absorption, distribution, metabolism and excretion (ADME) and pharmacokinetics of [14C]JDQ443 following a single oral dose of JDQ443 in healthy male participants.

In this study, we will investigate how quickly and to what extent JDQ443 is absorbed, transported, and eliminated from the body. JDQ443 will be radioactively labeled with carbon-14 (14C). In this way, JDQ443 can be traced in blood, urine, feces, and…

The nephroprotective effect of short hydration during cisplatin treatment in head and neck cancer patients.

To evaluate the incidence of CIN during cisplatin 40mg/m2 Q1W chemotherapy in patients with head and neck cancer and establish whether SH is superior to LH during cisplatin chemotherapy in reducing the incidence of AKI grade>=1.Secondary…

Superparamagnetic iron oxide-enhanced magnetic resonance imaging for sentinel lymph node identification in oral cancer: a feasibility study

To explore the feasibility of sentinel lymph node identification by SPIO injection followed by MRI in head-and-neck cancer patients.

A Phase 2/3, Randomized, Open-label Study to Compare Bempegaldesleukin Combined with Pembrolizumab Versus Pembrolizumab Alone in First-Line Treatment of Patients with Metastatic or Recurrent Head and Neck Squamous-Cell Carcinoma with PD-L1 Expressing Tumors (PROPEL-36)

In patients who are aged 18 years and older with recurrent or metastatic head and neck squamous-cell carcinoma (HNSCC)and positive programmed cell death ligand1 (PD-L1)expression (defined by combined positive score [CPS]*1) who have not received…

CT-venography compared to duplex ultrasound for detection of catheter-related thrombosis in cancer patients

The main objectives of this study are(I) to compare the sensitivity of CT-venography and ultrasound for screening-detected, catheter-related thrombosis in cancer patients and (II) to assess intrinsic coagulation levels in cancer patients prior to…