209 results
To enhance sustainable return to work of cancer survivors of working age.
The current study is a continuation of the cohort 5-8 years post-diagnosis and aims to evaluate:1.The course of the nutritional status, and the related factors and consequences of malnutrition in survivors of childhood cancer until 5-8 years post-…
The main aim of this study is to find out if the continuation of bevacizumab, in addition to standard 2nd & 3rd -line treatment, can help patients with NSCLC that has progressed to live longer. The study also aims to find out if continued…
PrimaryTo assess the efficacy of LEE011 compared to placebo in patients with relapsed/refractory teratoma with recent progressionSecondaryTo assess other measures of efficacy of LEE011 compared with placebo To assess safety and tolerability of…
Primary objective: To compare the severe (acute and late) toxicity (Grade 3-5), as assessed by CTCAE Version 4, caused by cetuximab and RT to that caused by cisplatin and RT in patients with HPV+OPSCC.Secondary objectives:- Compare overall number of…
Primary objective* To determine safety and the maximum tolerated dose (MTD) of SAR405838 through the characterization of dose-limiting toxicities (DLTs).* To assess biological activities of SAR405838 in patients with dedifferentiated liposarcoma…
We will investigate whether the Respecting Choices program will improve communication between patients and healthcare professionals, will improve the QOL and wellbeing of patients and their relatives, will reduce futile treatments and unnecessary…
We aim to test the effectiveness of a patient-targeted preparatory tool (*Gesprekswijzer*) and an oncologist-targeted communication skills training to enhance shared decision making in consultations about palliative systemic treatment. The primary…
The primary objective of the study is to gain insight in the short term and long term effects of the EFCT-ODA therapy on 1) dyadic coping abilities in the relationship and 2) relational satisfaction. Moreover, the process aspects of the ODA will be…
The main objective is to estimate the MTD(s) and/or RDE(s) of IDH305 in patients with IDH1R132 mutant malignancies, as measured by the incidence of dose-limiting toxicities.Secondary objectives are characterization of the safety, tolerability, PK…
Primary objectives:- To evaluate the toxicity and feasibility of a DLI-combined minor H ag UTA2-1 peptide-loaded, PD-L silenced donor DC vaccination in B cell hematological malignancies- To evaluate the effect of a DLI-combined minor H ag UTA2-1…
To compare the effects of exercise therapy on mouth opening using the TheraBite and the DTS in a randomized controlled trial in head and neck cancer patients suffering from trismus.
Primary Objectives* Phase 1b lead-in: To assess safety and tolerability of a single dose level of avelumab in combination withincreasing dose levels of other immune modulators in combination with a single doselevel of avelumab in patients with…
Primary objective is to demonstrate a 25% reduction of the active irinotecan metabolite, SN38, in healthy liver tissue in patients with mCRC or other solid tumors as a result of preceding dietary restriction five days in advance. Secondary…
The main objective of this study is to develop a PDT and salvage surgery combination specific for recurrent or residual tumors of the sinonasal cavities, unsuitable for the conventional treatments like radical surgery or radiotherapy with curative…
The purpose of this study is to investigate how safe the new compound FLX475 is when it is administered to healthy subjects. FLX475 has not been administered to humans before. It has been previously tested in the laboratory and on animals. FLX475…
The primary objective of the study is to determine the mean prediction error (MPE) and mean absolute prediction error (MAPE) of the area under the plasma concentration-time curve (AUC) of carboplatin after adjusted dosing for high BMI (BMI >…
The primary objective of the study is to assess the anti-tumor activity for patients with GBM with a translocation or amplification in FGFR1,2,3 or 4 based on PFS.The secondary objectives of the study are to assess the anti-tumor activity for…
Primary objective: To determine the MTD/highest studied dose determined to be safe, the safety and tolerability of INC280 as a single agent when administered orally to adult patients with c-MET dependent advanced solid malignancies.Secondary…
Based on the data available, Anamorelin HCl produces an increase in total body weight and Lean Body Mass in patients with advanced cancer, and specifically in patients with NSCLC, in addition to increasing muscle strength and improving quality of…