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Imaging the effect of HSP90 inhibitor AUY922 on HER2 expression by means of 89Zr-trastuzumab PET. A side study to the phase I-II study with AUY922 in either HER2 or ER positive locally advanced or metastatic breast cancer: protocol CAUY922A2101.

To show the effect of the HSP90 inhibitor AUY922 on HER2 expression by means of 89Zr-trastuzumab PET scanning. Primary endpoint: measurement of decreased HER2 expression compared to baseline. A decline is defined as a decrease of at least 30% in…

The mechanism of paraganglioma tumorigenesis

The main goal of this project is the elucidation of the mechanism underlying the paternal inheritance seen in SDHD- and SDHAF2-related paraganglioma. The results of this project should aid us in the identification of the *modifier* gene, essential…

The effect of transsphenoidal pituitary adenomectomy on macular ganglion cell thickness, post-illumination pupil response, and sleep-wake rhythm

The primary objective of this study is to determine the effect of transsphenoidal adenomectomy on parameters of macular ganglion cell thickness and the PIPR in patients with optic chiasm compression. The main secondary objective is to assess the…