48 results
To investigate whether therapy with the tyrosine kinase inhibitor Sorafenib will increase the accumulation of radioiodine (RaI) and decrease tumor progression in patients with recurrences or metastases of non-medullary thyroid carcinoma with absent…
This study aims to investigate if optimal personalized consultation by a dietician for a healthy diet focused on food which contains sufficient vitamins and minerals improves gastrointestinal symptoms as determined by an improved score in the…
This study aims to investigate if the proportion of NET patients with normal vitamin values can be increased, with vitamin suppletion and a personalized diet, measured with quantitative analysis of blood and urine. Secondary aims are an improvement…
Primary objective(s): To assess the effect of LysaKare® administration on serum potassium concentration in GEP-NET patients eligible for Lutathera® treatmentSecondary objective(s): To confirm the safety profile of LysaKare® infusion in GEP-NET…
Primary Objective: To assess the transcriptional, epigenetic and functional reprogramming of TAMs, circulating monocytes and BM myeloid progenitors cells in active and advanced metastatic TC and to assess the effect of RAI treatment on the…
The objective of this study is to evaluate the effect of cabozantinib compared with placebo on PFS and ORR in subjects with RAI-refractory DTC who have progressed after prior VEGFR-targeted therapy.
To monitor safety, implementation and effectiveness of active surveillance before the final results of the SANO trial are available in patients outside a randomized clinical trial.
Finding the maximum tolerated dose for MRI guided radiotherapy on upper abdomen malignancies in particular pancreatic malignancies.
This project aims to explore the efficacy and safety of radiotherapy for asymptomatic pNET using delivery of radiotherapy by MR-linac in Multiple Endocrine Neoplasia 1 (MEN1) patients.
Primary objectives:• Evaluate organ absorbed radiation doses from PRRT with Lutathera in adolescent patients with SSTR-positive GEP-NETs• Evaluate safety and tolerability of Lutathera in adolescents with SSTR-positive GEP-NETsSecondary objectives:•…
Primary objective: 1. To compare the difference in thyroid uptake of a low tracer dose radioactive iodine (10 MBq 123I or 37 MBq 123I) (1a), in DTC patients after thyroidectomy, before and after a LID of 7 days (1b).Primary objective described in…
In the iNode project we want to show it is technically possible to irradiate individual lymph nodes. For this reason, we will treat 20 patients with laryngeal, hypopharyngeal or oropharyngeal cancer with radiation. The radiation dose will be applied…
This study has been transitioned to CTIS with ID 2023-509334-19-00 check the CTIS register for the current data. This study aims to determine the safety, pharmacokinetics (PK) and recommended Phase 3 dose (RP3D) of RYZ101 in Part 1, and the safety,…
The aim of this prospective proof-of-concept study is to increase the expression of the SSTR2 in NET patients with negative or low expression to levels amenable for somatostatin analogue treatment through the use of epigenetic drugs.
Determine the fraction of RAI-R thyroid cancer patients who are eligible for I-131 therapy after 6- or 12-week lenvatinib treatment to an extent that clinically meaningful tumour radiation doses [Gy] can be safely delivered with acceptable I-131…
The purpose of this study is to compare STZ vs everolimus as first line treatment for advanced pNET and elucidate which sequence of STZ based chemotherapy and the mTOR inhibitor, everolimus, gives better results in terms of PFS in well…
To test the feasibility and safety of minimally invasive CT-guided percutaneous holmium-166 microsphere brachytherapy in patients suffering from irresectable pancreatic cancer.
To assess the transcriptional, epigenetic and functional reprogramming of circulating monocytes and BM myeloid progenitor cells in TC, CC and melanoma before and after in vitro exposure to agents that induce trained immunity.
This study has been transitioned to CTIS with ID 2024-513007-14-00 check the CTIS register for the current data. The current trial aims to asses the safety of this combination in a phase I trial with olaparib dose escalation during two cycles of…
This study has been transitioned to CTIS with ID 2024-516126-54-00 check the CTIS register for the current data. The main objective of this study is to study the feasibility and efficacy of neo-adjuvant treatment with BRAF/MEK inhibition to increase…