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AN OPEN-LABEL, EXTENSION (ROLLOVER) STUDY OF VEMURAFENIB IN PATIENTS WITH BRAFV600 MUTATION*POSITIVE MALIGNANCIES PREVIOUSLY ENROLLED IN AN ANTECEDENT VEMURAFENIB PROTOCOL

The primary objective of this study is to provide continued access to vemurafenib for eligible patients with BRAFV600 mutation-positive malignancy who were previously treated in an antecedent vemurafenib protocol and did not meet the protocol*s…

Three non-invasive Treatment Options for superficial basal cell carcinoma:
PDT vs. imiquimod vs. 5-fluorouracil

This research has the goal to determine which treatment is the most effective treatment in terms of prevention of treatment failure, in costs and has the patients preference when comparing PDT, Imiquimod and 5FU.

Treatment of anal intraepithelial neoplasia in HIV-positive patients, a triple-arm randomized clinical trial

To establish the preferred treatment of AIN to prevent the development of severe anal neoplasia (persistent AIN III or anal carcinoma) in HIV+ MSM and HIV+ woman.

Topical Ingenol mebutate versus 5% 5-fluorouracil versus 5% Imiquimod versus photodynamic therapy in treatment of actinic keratosis: a multi-center randomized efficacy and cost-effectiveness study

Determine which treatment is the most effective treatment in terms of lesion reduction, costs and patient satisfaction when comparing topical treatment with photodynamic therapy (PDT), 5% 5-fluorouracil (5-FU) cream, 5% Imiquimod (IMI) cream and…

Surgical excision versus photodynamic therapy and topical 5-fluorouracil in treatment of Bowen*s disease: a multicenter randomized controlled trial

Primary Objective: To determine the (cost)effectiveness of 5-fluorouracil cream (5FU) and photodynamic therapy (PDT), compared to surgical excision (SE) in Bowen*s Disease (BD).Secondary Objectives: To determine the (cost)effectiveness of 5-…