50 results
Primary objective: To evaluate whole body distribution of 89Zr-pembrolizumab in patients with locally advanced or metastatic melanoma or NSCLC. Secondary objectives: i) To evaluate pharmacokinetics of 89Zr-pembrolizumab; ii) To assess the…
To study whether either early 18F-FDG or 18F-FLT PET is superior in detecting response to treatment with the combination of vemurafenib plus cobimetinib (GDC-0973) compared to standard response assessment with CT and to evaluate whether, and which,…
The primary objective is to evaluate possible clinical effects correlated with α3β1 and CD151 expression in human epidermal malignancies, and relate these findings to the effects of α3β1 and CD151 deficiencies in skin cancer in the mouse.…
Primary: to compare the OSS concept with RCM in the surgical treatment of BCCs with current standard of care.Secondary: to assess the accuracy (sensitivity and specificity) of diagnosing BCC by comparing RCM with punch biopsy as diagnostic tools.…
1. Test if serum levels of S-100B are elevated in serum that contains frozen adipocytes2. Test if serum levels of S-100B are elevated in serum that was collected with a troublesome venipuncture 3. Test if serum levels of S-100B are lower in the…
To compare ICG-99Tc-nanocolloid to 99mTc-Senti-Scint for sentinel node mapping in patients with malignant melanoma of the trunk, an extremity or in the head and neck area.
To establish the diagnostic value of clinical diagnosis to predict the histological BCC subtype and compare this by the diagnostic accuracy of PB to determine the subtype of BCC in the subsequent SE/MMS specimen.
Primary Objective: To quantify the tissue light scattering, absorbing and fluorescence properties of different stages of skin (pre)cancer using multi-diameter single fiber reflectance (MDSFR) spectroscopy. Secondary Objective(s): To correlate the…
With this pilot study we aim to prove that our optical spectroscopy system can provide accurate identification of nerve tissue during surgery.
There's alack of randomized controlled trials for the treatment of primary squamous cell carcinoma of the skin and randomized comparative studies are recommended. With this pilot study, we want to study the effectiveness of Mohs'…
The primary aim of the study is the validation of the dermatoscope as a diagnostic aid for analyzing patients who visit the GP with the suspicion of a skin malignancy.Secondary aims of the study are the determination of the extent of health care…
A pilot feasibility study (n=5) will be performed to evaluate the feasibility (logistics, timing) and safety of administering autologous tumor infiltrating lymphocytes (TIL) generated at the NKI-AVL infused in conjunction with systemic high-dose…
The objective of the present study is to investigate the possbility to discriminate between actinic keratoses an dcutaneous squamous cell carcinoma with fluorescence diagnosis.
The aim of this study is to study whether the symptom pain is a diagnostic marker for a cutaneous squamous cell carcinoma.
To establish the preferred treatment of AIN to prevent the development of severe anal neoplasia (persistent AIN III or anal carcinoma) in HIV+ MSM and HIV+ woman.
To identify biological effects of bevacizumab therapy and to visualize distribution kinetics of 111In-bevacizumab with gamma-camera imaging.
Identification of predictive parameters for colitis in melanoma patients treated with immunotherapy.
To identify predictive parameters for colitis in melanoma patients treated with immunotherapy
The principal objective of the study is to determine if the performance of the new technique (magnetic tracer and magnetometer) is equivalent to the performance of the standard technique (patent blue dye and radioistope; or radioisotope alone). The…
Primary objective: To determine safety, feasibility, and the immune-activating capacity of short-term combined neo-adjuvant and adjuvant ipilimumab + nivolumab.Secondary objectives: To determine relapse free survival (RFS), any late adverse events,…
RESEARCH QUESTION(S): Can in vivo reflectance confocal microscopy (RCM) correctly identify the subtype of basal cellcarcinoma (BCC)?Primary Objective: To study whether in vivo reflectance confocal microscopy (RCM) can correctly identify the subtype…