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Age-related changes of the immune system leading to hyporesponsiveness; a major player and predictor for biological behaviour of metastasized melanoma?

To study the frequencies and differentiation status of CD4 and CD8 T cell populations (Tnaive, TCM, TEM, TEMRA) in young (18-50) and old (>65) treatment naive metastasized melanoma patients at baseline and after treatment.

Metastases of cutaneous squamous cell carcinoma in organ transplant recipients - The *SCOPE-ITSCC metastases study*

The objective of this multicenter prospective observational study is to estimate in a follow-up period of 2 years the cumulative incidence of metastases in OTR with cutaneous invasive SCC. In addition we will estimate the contribution of risk…

Risk factors for non-melanoma skin cancer (NMSC)
1. Skin carcinoma progression analyzed by genome-wide gene expression profiling and mimicked by validated organotypic in vitro human skin cancer models; towards an integrative system-biology approach and an in vitro screening method for targeted skin cancer therapies.
2. Genetic and environmental risk factors for the development of skin cancer in organ-transplant recipients.

Study 1:The ultimate goal is to abrogate or reduce the excessive burden of carcinomas in organ transplant patients. We aim to elucidate and establish consistent changes in genomic and expression (both mRNA and miRNA) profiles in the course of tumor…

Risk factors for scrotal cancer in the Netherlands

To identify risk factors for scrotal cancer

Molecular pathology of skin disease

To elucidate the molecular basis of skin disease.

Ultraviolet related DNA-damage in skin of patients with atopic dermatitis and atopic status in relation to the use of Myfortic®

The primary aim is to study the effect of treatment of severe AD patients with Myfortic on DNA-repair after irradiation with UVB.A secondary aim is to study the effect of treatment of severe AD patients on atopic status, measured as total IgE and…

DNA methylation profiling in blood of patients with cutaneous squamous cell carcinoma (cSCC) after organ transplantation

The main objective of this study is to identify changes in DNA methylation of CD3+ T cells associated with cSCC after organ transplantation.

Quality of life, cognitive function, and physical fitness of patients surviving more than 2 years after immune checkpoint inhibitor therapy

Primary Objective: - to investigate health-related quality of life (HRQoL) of patients surviving 2 years or more after the first cycle of an immune checkpoint inhibitor for melanoma or NSCLC.Secondary Objectives:- to assess neurocognitive function,…