39 results
The primary objective of this study is to optimize a workflow for identification of circulating melanoma cells in LA using flow cytometry. Secondary objectives include the detection of known mutations in different CMC subsets.
To investigate the effects of ICIs (anti-CTLA4, anti-PD1, combination anti-CTLA4/PD1) on vascular inflammation (PET-CT) in stage III melanoma patients. We hypothesize that the increase in vascular inflammation will be greater in the exposure group…
Primary Objectives- To investigate the impact of dose reduction of 18F-FDG on image quality of PET-MRII in patients with melanoma. Secondary Objectives- To determine the maximum reduction of radiation dose for 18F-FDG PET-MRI as compared to…
In this study we clinically validate if host cell DNA methylation markers can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance and the safety of withholding treatment. This could prevent…
To investigate the added value of OCT as a non-invasive tool for the diagnosis of recurrent BCC.
Primary Objective: - Investigate whether recirculating tumor-associated tissue macrophages (TiMas), as well as circulating melanoma cells can be detected using high-end flow cytometry methods in peripheral blood from melanoma patients.Secondary…
The primary objective of this study is to evaluate the feasibility and diagnostic accuracy of pre-operative MRI scanning using SPIO compared to lymphoscintigraphy (LS) and single-photon emission computed tomography/computed tomography (SPECT/CT)…
This study has been transitioned to CTIS with ID 2024-516547-11-00 check the CTIS register for the current data. To assess uptake (visual and quantitative) of 89Zr-ipilimumab in tumor lesions and biodistribution at start of nivolumab/ipilimumab…
PRIMARY OBJECTIVETo assess the diagnostic performances (specificity, sensitivity, positive and negative predictive values) of monitoring blood biomarkers (T-Ag antibodies and miR375 levels) for detection of recurrence of disease during follow up.…
The purpose of the current study is to determine the feasibility of using MFGS using Cetuximab-800CW as an intraoperative margin assessment tool for penile carcinoma.
Primary ObjectiveSafety Lead-in* Evaluate the safety of a high-dose regimen of encorafenib + binimetinib combination therapy in patients with BRAFV600-mutant melanoma who have asymptomatic brain metastasisPhase 2If the high-dose regimen is…
- The technical feasibility of multispectral optoacoustic tomography for the localization and assessment of disease-specific tissue in a particular anatomical area- Detection of endogenous biomarkers for the characterization in a variety of diseases
The main purpose is to establish the intraoperative use of cetuximab-IRDye800CW as a reliable marker for residual tumor in resection margins after surgical removal of HNSCC. The objective is to establish the positive predictive value of cetuximab-…
The primary objective of this study, including healthy subjects, is to develop a pre-operative MRI protocol for the localization of SLNs in melanoma patients. Acquired knowledge will serve to design a feasibility study, including a larger group of…
Determining the robustness of [18F]-FDG PET/CT based quantitative features in metastatic melanoma patients by test-retesting [18F]-FDG PET/CT scans and varying post processing scan settings, for future diagnostic and prognostic clinical application.
The main purpose of this pilot study is to investigate the feasibility of fluorescence imaging using cetuximab-IRDye800CW for intraoperative margin assessment in patients with cutaneous squamous cell carcinoma.
Primary Objective: • To investigate the feasibility of utilizing PAI as a means of detecting the SLN in patients with melanoma or breast cancerSecondary Objective(s): • Determine the most effective wavelengths for detecting ICG in PAI• Investigate…
In this pilot study we want to evaluate the clinical use of the DiffMag handheld probe, and compare the detection and usability of the DiffMag with the radioactive detection and the detection of the SentiMag for furthur optimazation of DiffMag…
The primary aim of this proof of principle (POP) and pharmacological study is to demonstrate significant anti-tumor activity of vorinostat in advanced resistant BRAF V600 melanoma and secondary aims are to explore the safety, pharmacokinetics and…