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Prophylactic infusion of CD4 positive donor lymphocytes early after T-cell depleted allogeneic stem cell transplantation in patients with an unrelated donor

In this phase II study, the toxicity and treatment effects of early donor derived CD4+ lymphocyte infusion, three months after allo-SCT, will be evaluated

TropicALL study; Thromboprophylaxis in Children treated for Acute Lymphoblastic Leukemia with
Low-molecular-weight heparin: a randomized controlled trial

Main objective:To assess the efficacy of thromboprophylaxis with high prophylactic dose LMWH as compared with standard care without systemic thromboprophylaxis in children treated for primary ALL during asparaginase treatment.Secondary objectives:1…

Platelet activity test study

In the platelet activity test study (PATS) we aim to perform a pilot to validate the platelet activity test for use in our laboratory and test the logistics of sample processing, in the setting of the BOP study, before starting the clinical trial in…

Immunological monitoring and assessment of biomarkers predictive of clinical response to first-line treatment with bosutinib or imatinib in chronic phase chronic myeloid leukemia

In this laboratory study, we will examine the properties of leukemic stem cells and the immuno-modulatory effects of bosutinib and imatinib in newly diagnosed chronic phase CML patients. Further, we aim to study whether they have an impact on the…

Health related quality of life (HRQoL) in childhood survivors of refractory GvHD treated with mesenchymal stromal cell infusions - a multi-center study

We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…

Pilot intervention study aimed at reducing stress in parents of children undergoing SCT

The objective of this study is to adapt and pilot an existing psychological intervention program (SCCIP-ND, mentioned above) to alleviate anxiety and distress and to prevent PTSS in parents of pediatric patients who are receiving stem cell…

Is early revaccination after ALL therapy feasible ?
Evaluation of loss of antibodies and responsiveness to (re-)vaccination in children after treatment for acute lymphocytic leukemia.

To determine effect of early (re) vaccinations after the current intensive chemotherapy for ALL. We will determine if there is a difference in respons to conjugated (T cell dependent) and polysaccharide (T cell independent) vaccines. This may result…

Phase 1B Study of the Safety, Tolerance, and Pharmacokinetics of Oral Posaconazole in Immunocompromised Children With Neutropenia

The primary objective of this study is to evaluate the PK of POS administered orally at three dosage levels to immunocompromised children with expected neutropenia (selected oncology patients, aplastic anemia patients and patients which undergo a…

The efficacy of an on-line coaching program focussing on the promotion of an active lifestyle in children after medical cancer treatment.

The goal of this study is to test the greater efficacy of the *COME ON, move on!* program in children, who received medical treatment for cancer, compared to pediatric physical therapy treatments without intensive coaching by Internet. This new…

Neurotoxicity of cancer treatment: Neurocognitive dysfunction and underlying mechanisms

With this information we hope to be able provide ex-patients with more detailed information about late effects of treatment. Also it is a very important step towards ajusting current treatment protocol to prevent late effects as much as possible.

DREAMS II Study; HPA axis function and sympathetic nervous system activity in survivors of childhood acute lymphoblastic leukemia

To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.

Target attainment of ciprofloxacin as infection prophylaxis during chemotherapy-induced neutropenia in patients treated for haematological malignancies.

Prospectively investigate whether ciprofloxacin, administered as antibiotic prophylaxis in patients treated for haematological malignancies (with or without gastro-intestinal mucositis), in the currently recommended dosing regimen (500 mg orally or…

Isolation, immortalization and characterization of human B lymphocytes for the development of diagnostic and therapeutic antibodies against cancer.

Until recently, the field of anti-tumor immunology has focussed on the role of T lymphocytes. Recently, however, the group of prof. H. Spits and dr. T. Beaumont developed an in vitro methodology to grow human, monoclonal, B cell receptor positive…

Short-term combined acalabrutinib and venetoclax treatment of newly diagnosed patients with CLL at high risk of infection and/or early treatment, who do not fulfil IWCLL treatment criteria for treatment. A randomized study with extensive immune phenotyping.

This study has been transitioned to CTIS with ID 2024-511072-33-00 check the CTIS register for the current data. The aim is thereby to reduce the risk of serious infections and the need for regular CLL treatment.

An open-label, randomized clinical trial on teicoplanin infection prophylaxis in pediatric patients with acute myeloid leukemia

This study has been transitioned to CTIS with ID 2023-506546-23-00 check the CTIS register for the current data. Objectives safety run-in: The primary objective is:• To assess the safety of i.v. teicoplanin prophylaxis three times per week with a…