14 results
To study whether CMR analysisdifferences in aortic stiffness and myocardial lipid accumulation between SCT recipients and healthy, age-matched controls
Primary ObjectiveTo assess the capability of the dPCR technique to predict the absence of disease relapses after imatinib discontinuation in CML patients with negative Q-RT-PCR results for longer than 18 months.Secondary Objectives• To estimate…
Primary aims:1. To perform a population-based screen to estimate the exact frequency ot transient leukemia in Dutch newborns with Down syndrome2. To investigate the realtionship between transient leukemia and the occurrence of DS ML and ALL at later…
The main purpose of this study is to investigate the effect of ASTX660 on how quickly and to what extent quinidine and fexofenadine are absorbed, distributed, broken down and eliminated from the body. Quinidine and fexofenadine have been chosen…
Primary objectives:- Overall: Improvement of event-free survival (EFS) probabilities in childhood relapsed ALL- Randomization 1: EFS of Arm A (ALL-REZ BFM 2002) versus B (ALLR3) in SR patients- Randomization 2: Influence of epratuzumab on EFS in…
Generation of (age-dependent) reference values **of leukocytes and their subtypes and of their products, as well as analysis of (age-dependent) IG / TR repertoire. In order to be able to distinguish the age-dependent effects from effects caused by…
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10.This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
Primary Objective:Efficacy:· Evaluate the efficacy of subcutaneous (sc) azacitidine in combination with durvalumab as compared with subcutaneous azacitidine alone in the defined study population.Secondary Objectives:Safety:· Assess the safety and…
Our research aims to determine and compare MRD in BM and PB with our current qualified MRD test. The study takes place in at the Amsterdam UMC location VUmc. We take two extra tubes (14 ml total) of heparin blood at the same day as the planned BM…
1. Optimise the DNA extraction process on serum and plasma to increase the sensitivity of DNA-based fungal infection diagnostic test (especially genetic mutations conferring azole resistance in invasive aspergillosis). 2. Evaluate new targeted as…
Overall objective of this IDeAL study is to unravel the biological heterogeneity of LGL leukemia and to correlate this with the clinical features. More specific objectives are: 1. Build a LGL leukemia registry (clinical features and lab data).2. Set…
This study has been transitioned to CTIS with ID 2024-518254-16-00 check the CTIS register for the current data. The primary aim of the NOPHO-DBH AML 2012 study is to improve EFS and OS in children with AML. To improve outcome, an intensified…
To assess whether an adequate response to pneumococcal antigen, as a marker of overall humoral immune system reactivity, predicts sustained TFR. An adequate response to pneumococcal antigen will be defined as achieving anti-pneumococcal IgG levels…
The objective of the study is to demonstrate the accuracy (positive and negative percent agreement) by comparing AMLProfiler results from fresh and banked, AML, APL and RAEB bone marrow samples at multiple participating clinical sites with results…