22 results
This project aims to achieve advances in understanding CLL initiation and progression, and to identify novel targets for therapy of CLL, through a detailed genetic and immunological comparison of manifest CLL and MBL as the premalignant counterpart…
The objectives of this pilot study are to explore differences in sleep and fatigue, and the relation with the function of the HPA axis, between survivors of childhood ALL and healthy controls.
The present study will be focused to define the underlying mechanism of resistance in the malignant cells by analyzing the process of proliferation and differentiation in conjunction with the gene profiling and definition of new molecular markers.
In the platelet activity test study (PATS) we aim to perform a pilot to validate the platelet activity test for use in our laboratory and test the logistics of sample processing, in the setting of the BOP study, before starting the clinical trial in…
To study HPA axis regulation and sympathetic nervous system activity in survivors of childhood ALL during relaxation and during stress.
The aim of the study is to:1. Attain more insight in the biology of ageing of hematopoietic stem cells2. Attain more insight in the relation between ageing and cancer
1 To determine the phenotype and biological characteristics of mesenchymal stem cells derived from pediatric MDS patients as determined by flow cytometric analysis, cell culture and differentiation abilities analyzed by subtype of MDS compared to de…
To investigate the clinical and biological characteristics of MBL in order to obtain insight into CLL leukemogenesis and disease progression.
The goal of this study is to test the greater efficacy of the *COME ON, move on!* program in children, who received medical treatment for cancer, compared to pediatric physical therapy treatments without intensive coaching by Internet. This new…
To identify the differences in gene expression profiles of leukemic cells in lymph nodes and bone marrow versus peripheral blood in patients with chronic lymphocytic leukemia. Thereby investigating which differences are important in the resistance…
The objective of this study is to adapt and pilot an existing psychological intervention program (SCCIP-ND, mentioned above) to alleviate anxiety and distress and to prevent PTSS in parents of pediatric patients who are receiving stem cell…
We propose to investigate the health related quality of life (HRQoL) in childhood survivors of refractory GvHD who have been treated with mesenchymal stem cell transfusions. This will be a multi center study involving the Division of Clinical…
In this laboratory study, we will examine the properties of leukemic stem cells and the immuno-modulatory effects of bosutinib and imatinib in newly diagnosed chronic phase CML patients. Further, we aim to study whether they have an impact on the…
We aim to quantify the contribution of individual HSCs to blood (re-)generation in pediatric HSCT recipients and their donors, and to unravel the consequences of transplantation on HSC long-term genomic integrity.
To determine the real world response to standard of care CAR T-cell therapy, in order to better understand the intrinsic and extrinsic factors related to treatment success or failure.
HSCT cohort:* -To investigate the relationship between IFNγ levels and IFNγ activity by measuring CXCL9 levels and the risk of graft failure* -To investigate the relationship between IFNγ levels and IFNγ activity by measuring CXCL9 levels and the…
Brain tumors: Characterize and quantify changes in immune parameters during disease in patients with a CNS malignancyAML: Characterize and quantify changes in immune parameters and immunotherapeutic targets during disease in pediatric patients with…
The current study aims to compare skeletal muscle glucose uptake after 1) an exercise stimulus and 2) under hyperinsulinemic conditions between CML patients on nilotinib, CML patients on imatinib and non-CML controls.
Primary objective: To study the prevalence and nature of taste and smell disturbances in GvHD patients. Secondary objective: To study whether the prevalence and nature of taste and smell disturbances are related to - oral GvHD - salivary flow - oral…
With this information we hope to be able provide ex-patients with more detailed information about late effects of treatment. Also it is a very important step towards ajusting current treatment protocol to prevent late effects as much as possible.