227 results
1) To obtain insight into the age-specific seroprevalence (immunity) for selected vaccine-preventable diseases among adult refugees in order to determine the need for targeted vaccination campaigns among identified risk groups (age, country of…
1. To optimize sorafenib treatment in patients with HCC and CP-B liver cirrhosis by exploration of sorafenib exposure, its variability and predictive factors .Secondary:2. To assess the relation between sorafenib exposure and both toxicity and…
The primary objective of this study is to evaluate the safety in terms of complication rate of IRE in the treatment of colorectal liver metastasis/es <3,5 cm in patients undergoing surgical resection (metastatectomy, segmental liver resection…
The overall goal of this RCT is to compare the efficacy of 90Y-RE to TACE-DEB, for patients with intermediate stage HCC. Time to progression, overall survival, tumor response, adverse events, treatment related effect on total liver function, quality…
Main objectiveTo investigate feasibility and safety of tumor ablation using IRE in patients with irresectable locally advanced pancreatic head carcinomas.Secondary objective(s)To investigate tumor downstaging efficacy, pain perception and hospital…
Trial objectivesThe objective of the phase I is to assess the feasibility and safety of radiotherapy (RT) in hepatocellularcarcinoma (HCC).The objective of the phase II is to assess the efficacy and safety of RT in HCC.Additional research…
To evaluate the efficacy and safety of BIBF 1120 in HCC patients without prior systemic treatment as compared to Sorafenib.
Primary objective:To determine target lesions tumour response.Secondary objectives:* To determine overall tumour response.* To determine the liver specific progression-free survival.* To determine non-liver specific progression-free survival.* To…
To investigate the release of damage-associated molecular patterns (DAMPs) following major hepatic resection with or without VIO and to correlate the outcomes to the acute inflammatory response and clinical parameters for hepatocellular damage.
To compare the number of responders to vaccination with the influenza virus vaccine and pneumococcal vaccine at different time points in treatment cycle of lenalidomide. Secondly to study the immune-response to vaccination, during treatment with…
Primary Objective: To compare the expression of inhibitory receptors SIRL-1 and LAIR-1 on blood neutrophils of patients under age 12 admitted with sepsis to the paediatric intensive care with healthy controls and intensive care patients without…
This trial will be a first-in-man study. It should therefore demonstrate the feasibility and accuracy of liver tumor ablation. Since image-guided tumor ablation techniques, such as MR-HIFU, leave the coagulated tumor in situ, treatment accuracy is…
The aim of this study is to evaluate the predictive value of a blood cell derived score, ICIS, for microbial infection, its likelihood, its invasiveness (blood stream infection) and severity (septic shock or mortality) in patients after lung or…
To investigate the effect of expanded adipose-derived allogeneic adult stem cells (eASCs) on the inflammatory response to intravenous LPS in humans.
The objective of this observational pilot is the evaluation of incidence of HSMO- and HRMO-carriage, evaluation of oral and gut microbiota before, during and after hospitalization and evaluation of health status related to an ecological niche of…
Introduction of dovitinib in the neo-adjuvant setting, can provide both clinical informationabout it*s activity in patients with HCC (reduction of tumor size, influence on the tumor bloodflow as assessed by CT perfusion imaging) and (histo-)…
Investigate the prevalence of rhinosinusitis and/or nasal polyps in adult patients with Cystic Fibrosis. Also several aspects of sinonasal disease are investigated; quality of life, correlation between phenotype and genotype, microbiology, anatomy…
Project description:A controlled randomized multicentre prospective clinical trial of 12 months duration at 5 centres. To evaluate and compare appliance of porous titanium granules (PTG) during surgical treatment of peri-implant osseous defects of…
To determine the choline levels of FNH, HCA and HCC using proton Magnetic Resonance Spectroscopy (expressed as parts per million).
1. to investigate the prognostic relevance of [18F]FLT uptake in resectable liver metastases of patients with colorectal cancer, in addition to existing prognostic indices with respect to disease-free survival; 2. in chemonaive patients, to validate…