227 results
To investigate different types of biomarkers in blood from patients with a HPB malignancy, HPB related disease as well as from healthy volunteers in order to identify biomarkers that serve as early predictors for the development of HPB malignancies…
This study has been transitioned to CTIS with ID 2024-514049-13-01 check the CTIS register for the current data. to study the anti-tumor effect of cannabis oil (THC10% / CBD5%) in untreatable advanced HCC patients based on imaging using RECIST and…
Aim of thus study is to observe and correlate the course of hepatic blood flow, liver function and liver regeneration after high risk liver surgery.Furthermore we aim to identify ultrasound, liver function and routine hemodynamic parameters…
The primary objectives are to demonstrate the safety and performance of the Exthera Medical Seraph 100 Microbind Affinity Blood Filter in the reduction of pathogen load from the blood in septic patients with suspected, life-threatening bloodstream…
Observational pilot study to investigate NGS as a reliable method to identify sepsis in neonates. NGS is proposed as a method to improve clinical identification, diagnosis and stratification of neonatal sepsis and provide basis for a more adequate…
The aim of the study is to improve the diagnostic tools of spontaneous bacterial peritonitis.The primary aim is to evaluate the use of dipsticks as bedside diagnostics compared to the current standard polymorphonuclear leukocyte count in identifying…
The main objective of this study is to determine the optimal dose and timing of the ICG injection by optimizing signal-to-background ratios in patients with colorectal liver metastases pretreated with chemotherapy to improve radical resection rates…
The aim of this study is to find out whether the addition of HAIP chemotherapy with floxuridin in patients with operable iCCA is effective, i.e. the time to recurrence is longer than with standard care.
To demonstrate the bioequivalence of sorafenib with probenecid relative to sorafenib without probenecid based on the AUC in patients with unresectable hepatocellular cancer, advanced clear-cell renal cell carcinoma, locally recurrent or metastatic,…
To elucidate the host and environmental factors that influence the magnitude of the individual trained immunity responses to BCG vaccination using a systems biology approach.
To assess feasibility of SBRT as add on treatment after standard chemotherapy.
1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10.This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…
Primary objective1. To test the safety of cold plasma treatment: SAE in * 10% of participants, no pain (VAT * 2) and no local skin reaction: redness, blister formation, pain or itching. Secondary objectives:The effect of cold plasma treatment on : 1…
Primary Objective: The first objective of this study is to evaluate the safety and feasibility of adjuvant HAIP chemotherapy after resection of CLM in 2 centres in the Netherlands.Secondary Objective(s): The second objective is to determine whether…
To gain insight into the effects of TAE on HCAs and their behavior post-embolisation.
The main objective is to assess hallmarks of protective and waning immunity to vaccine preventable and non-preventable viral and bacterial diseases.in cases of various age groups and age-matched healthy controls. Secondary objectives are 1) to…
The primary aim of this study is to describe the relationship of I/R injury during hepatic resection and hepatic microcirculation. The hypothesis is that the microcirculatory alterations concerning the total vessel density (TVD), microvascular flow…
To investigate whether using the ARC during 166Ho-RE increases the post-treatment tumor to non-tumor (T/N) activity concentration ratio, compared to using a standard end-hole microcatheter.
Quantification of postoperative change of liver function (measured with hepatobiliary scintigraphy). This change will be correlated with liver regeneration by measuring circulating regeneration-related biomarkers at different timepoints…
To assess the feasibility of real-time MRI temperature monitoring and ablation zone assessment during thermal ablation of liver tumours.