227 results
The aim of this study is to assess the clinical value of 99mTc-mebrofenin SPECT for the measurement of liver functional volume in patients planned for liver resection, in comparison to CT-volumetry. Furthermore, the significance of liver volume in…
To compare numbers of circulating T cells responding to different tumour-associated and viral antigens, as well plasma concentrations of antibodies against these antigens, before and after therapeutic interventions that destruct or debulk tumour…
Primary:- To investigate efficacy of PCT-guided antibiotic therapy in the ED- To evaluate the safety of PCT-guided antibiotic therapy in the ED - To determine and compare the accuracy of PCT and CRP as biomarker for bacterial infectionSecondary:- To…
Primary objective is to assess the efficacy of ablation therapy in combination with Y-90 radioembolization in patients with CRLM. Secondary objectives are: 1) Assessment of occurrence of any treatment related adverse events following ablation in…
To characterize the interaction between the genetic background, the microbiome, and the immune responses in patients with diabetes type 1, both cross-sectional and over time, and to identify the disturbances in this interaction.
(also see: C1. Protocol, page 12, paragraph 2)Primary Objective:Improving risk assessment of acute porphyric attacks and complications in patients with acute porphyria.Secondary Objectives: 1. Obtain and describe basic demographics and statistics,…
Therefore, we aim to define the pattern of lymphatic drainage from each of the liver segments, using standard lymphangiography during planned partial liver resection, thereby creating a *drainage map* of the human liver.
Pilot study:Primary objective: feasibilitySecondary objectives: response rate, time to progression, overall survival and quality of life.Phase II study:Primary objective: efficacy.Secondary objectives: toxicity, especially grade 3 and 4 toxicities,…
Comparison of the size and shape of the ablation zone of liver tumors with the simulation results of the CllnicIMPPACT software environment
To objectively investigate retinal function deterioration due to the inflammatory process by ERG. To investigate if risk factors for loss of ERG activity in uveitis herald more aggressive immunomodulation treatment to prevent visual loss.
This study aims to improve the diagnosis and management of febrile children across Europe and West Africa through the development of simple diagnostic tests to discriminate febrile illnesses in children, including bacterial and viral infection and…
The objective of this trial is to assess the immunological activity of Vvax001 by monitoring HPV-16 specific immune responses in order to determine the optimal dose inducing the highest immune responses.
In this study we hope to demonstrate the presence ofthat ctDNA can be reliably detected in patients with perihilar cholangiocarcinoma.
Primary objective * To determine the overall response rate of two PHP with an interval of at least 6 weeks and 3 mg/kg melphalan in irresectable liver metastases patients.* To determine the percentage of patients qualifying for resection. Secondary…
To optimize DCE-MRI, T2* MRI and DWI in pancreatic cancer at 3T and investigate its reproducibility.
To obtain insight into the age-specific seroprevalence (immunity) for diseases included in the NIP of the Dutch general population.
This study seeks to demonstrate the effectiveness and safety of the Non-Valved Conduit on the basis of infection. The rationale for infection resistance with the conduit is that Biointegral Surgical No-React® treated products have a well-documented…
The primary objective is to assess the (preliminary) effectiveness of a 4-week home-based exercise training program on an advanced cycle ergometer and the administration of nutritional supplements on preoperative aerobic capacity as measured by the…
Part 1: Dose-Escalation Stage (not in The Netherlands)Primary objective:* Safety and tolerability of HBM4003Secondary objectives:* Preliminary anti-tumor activities of HBM4003 in advanced solid tumors* Pharmacokinetics (PK) of HBM4003Other…
The primary aim of the study is to assess the prevalence of MDRO carriage in patients undergoing ERCPs. This will be performed in four different countries with expected significantly different prevalence rates of MDRO carriage, namely: India, United…