227 results
It is hypothesized that eRFA leads to increased stent patency, fewer re-interventions, fewer (permanent) external drains, and consequently increased quality of life. The primary aim of the proposed pilot study is to evaluate whether eRFA is feasible…
The primary objective of this trial is to determine clinical efficacy of Vvax001 in CIN3 patients.
DRAGON I is a pre-trial that aims to introduce PVE/HVE in liver surgery centers worldwide in a controlled fashion to ensuring patient safety, proper data monitoring and a critical assessment of efficacy. The goal of DRAGON 1 is to assemble the…
The aim of this study is to develop and evaluate a new ultrasound-based navigation system for guidance of resection and ablation of liver lesions during liver surgery. The feasibility and accuracy of this in-house developed navigation system is…
1. To describe mitoPO2 in clinically admitted critically ill septic patients receiving fluid therapy (consisting of crystalloid, albumin and/or red cell transfusion).2. To describe the effects of fluid therapy on mitoPO2 and on other physiological…
To investigate the feasibility of co-registration with MIRADA XD of pre- and post-ablation CT using an optimized scanning protocol. Secondary objectives will be to investigate the reproducibility of CT-CT co-registration, to determine the duration…
The primary aim of this study is to assess the feasibility of EM-navigation for percutaneous liver ablation.
To determine inter- and intra-fraction fiducial and patient position reproducibility in order to determine appropriate safety margins for liver SBRT treatment on Ethos.
Primary: Associate acquisition of pneumococcal colonisation with levels of pre-existing polysaccharide specific memory B cells. Secondary: a) To validate the use of synthetic absorptive matrices (SAM) for detection of other (non-pneumococcal)…
Primary Objective:To establish the maximum tolerated healthy liver-absorbed dose of 166Ho-microspheres in patients with HCC who receive RL as a bridge to resection.Secondary Objective(s): 1) To establish dose-response relationships between:a. The…
This study has been transitioned to CTIS with ID 2024-512622-29-00 check the CTIS register for the current data. To determine the maximum tolerated dose (MTD) and Recommended Phase 2 Dose (RP2D) of RLY-4008 and to determine RLY-4008's safety…
To investigate the safety and feasibility of a personalized Ho-166-PLLA-MS TARE approach by using MRI guidance in inoperable patients with HCC.
We compare the efficacy and safety of the new medication MTL-CEBPA in combination with sorafenib with the efficacy and safety of sorafenib alone. Sorafenib is already being used for the treatment of HCC.
The aim of the current study is to assess whether MI combined liver and colorectal resection for CRLMs and primary colorectal tumor can result in shorter time to functional recovery and hereby results indirectly in a lower postoperative complication…
Primary Objectives:Our primary objectives are:1. To evaluate the safety, tolerability and pharmacokinetics of intravenously (IV) administered M6229 in critically ill patients with sepsis with specific attention to anti-coagulation effects (based on…
To reduce stent dysfunction after EUS-CDS by placing a FCSEMS through the LAMS, while maintaining effectiveness and safety of EUS-CDS as primary drainage strategy in patients with malignant distal biliary obstruction.
This study is designed to examine beneficial effects of PLASOMA treatment compared to the standard of care on chronic venous leg ulcers (VLU) that match the size of the plasma area of the pad.The intention is that the data obtained with this study…
To evaluate our proposed SMS protocol in high-risk patients and compare it to a bi-annual US screening.
To explore feasibility and efficacy of endoscopic drainage of patients with presumed perihilar cholangiocarcinoma eligible for major liver resection using a plastic stent with a retrieval string.
This study has been transitioned to CTIS with ID 2024-517340-61-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the efficacy of gemcitabine and cisplatin compared with standard of care (adjuvant…