66 results
In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…
In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…
In order to confirm previous observations and to increase our understanding of the patho-physiologic mechanism of the plasma lipid changes; in this study, we will prospectively measure the blood lipid profile of approx. 120 malaria patients and an…
The objective of the study is to assess the additional value of monitoring segmental liver function with HBS in patients undergoing SIRT.
1. To assess the incidence of pulmonary infiltrates by means of low dose CT-scan in patients with a high clinical suspicion of CAP but with a normal chest x-ray 2. The levels of biomarkers (CRP, PCT, White blood cell count) will be compared to the…
In this study we will explore changes in the hepatic function after stimulation of hepatic cells with an oral food challenge, the **hepatocyte reserve capacity**. Moreover, we will explore potential differences in the hepatocyte reserve capacity…
Treatment strategy in early HCC aims at the local removal of the tumor and represents a potentially curative treatment option (resection, liver transplantation, PEI, RFA, BT). Patients in intermediate and advanced stage of HCC receive treatment with…
The aim of this study is to evaluate the predictive value of a blood cell derived score, ICIS, for microbial infection, its likelihood, its invasiveness (blood stream infection) and severity (septic shock or mortality) in patients after lung or…
1. to investigate the prognostic relevance of [18F]FLT uptake in resectable liver metastases of patients with colorectal cancer, in addition to existing prognostic indices with respect to disease-free survival; 2. in chemonaive patients, to validate…
To make an efficacy evaluation of Gadolineum Ethoxybenzyl (Gd-EOB) DTPA-enhanced MR-imaging (Gadoxetic acid, Primovist, Bayer Schering Pharma, Berlin) and Respiratory Triggered Diffusion Weighted Imaging (DWI) for the detection and characterization…
To assess whether radiofrequency ablation in the liver is associated with hypoxia in the rim of the induced necrosis.
For further details see - Protocol section: 2 - Aimo Assessment of the accuracy of the FCH PET/CT scan in diagnosing HCC. o Assesment of radical surgical resection, using the FCH PET/CTscan.o Assesment of recurrence after surgical resection, using…
The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.
This study aims to design a nomogram for the course of serum pro-calcitonin in burn patients. For this purpose, a new, sensitive assay will be used. It is expected that the nomogram will help to differentiate between patients with a systemic…
To evaluate the outcome of FISH testing with a set of biomarkers with regard to the prognostic value and the diagnostic accuracy for both sporadic cholangiocarcinoma and PSC related cholangiocarcinoma. Subsequently we want to develop a valid…
Aim of this study is to confirm the results from ex vivo research in humans in a clinical setting. The objective is to perform optical spectroscopy measurements during surgical procedures in vivo, involving resection of either breast, liver or lung…
Determine normal ADC values and the reproducibility of the ADC values in normal liver tissue and colorectal liver metastases in a multicentre trial. Determine the effect of lesion volume on reproducibility of the ADC values.
The primary objective of this study is to evaluate the ability of PET-MRI to detect LSR during the first year of follow-up after RFA treatment of CRLM as compared with ceCT and PET-CT. Standard reference will be histology (when available) or…
The aim of the present pilot study is to assess whether percutaneous optical spectroscopy can serve as a novel tool for tumour response evaluation in patients with unresectable colorectal liver metastases receiving first line systemic therapy.
Aim of this study is to assess the value of cholangioscopic directed biopsies versus brush cytology in differentiating between malignant and benign biliary strictures. Determination of tumor markers to improve early diagnosis of malignant biliary…