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Protocol ALL-11:Treatment study protocol of the Dutch Childhood Oncology Group for children and adolescents (1-19 year) with newly diagnosed acute lymphoblastic leukemia

1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10.This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…

Functional and biochemical assessment of liver regeneration after major hepatectomy

Quantification of postoperative change of liver function (measured with hepatobiliary scintigraphy). This change will be correlated with liver regeneration by measuring circulating regeneration-related biomarkers at different timepoints…

Evaluation of a non-invasive dynamic light scattering sensor for the measurement of heart rate in neonates.

Our primary objective is to correlate the measured heart rates between ECG measurements and the Elfi-Tech dynamic light scattering sensor.

The relationship between contrast media volume and tube voltage in computed tomography of the liver, for optimal enhancement based on total body weight: A randomized controlled trial. [COMpLEx trial]

The aim of present study is to investigate if adapting the dosing factor based on TBW and therefore the CM volume to the tube voltage used, results in a more homogeneous liver enhancement. We hope to find a more homogeneous enhancement between…

Real-time MR imaged treatment with holmium microspheres of patients with primary or secondary liver cancer; a single center, interventional, non-randomized, feasibility study.

The main objective of this project is to demonstrate the feasibility and safety of real-time imaged radioembolisation with holmium microspheres.

Assessment of liver function with Dynamic Contrast-Enhanced MRI in patients scheduled for liver resection - a pilot study.

To compare DCE-MRI of the liver with the liver-specific contrast agent Gd-EOB-DTPA with 99mTC-HBS in patients scheduled for liver resection in estimation of (regional) liver function.