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Discrimination of benign and malignant human tissue during percutaneous interventions using optical spectroscopy techniques

In our previous studies using optical spectroscopy, both ex vivo and in vivo, most promising results were obtained for tissue diagnosis. Moreover, invasive procedures for biopsy or radiofrequency ablation in these tissues are all very common. Thus,…

Pilot-study: Investigation of the safety of irreversible electroporation (IRE) as novel treatment for colorectal liver metastases - a phase I clinical study

The primary objective of this study is to evaluate the safety in terms of complication rate of IRE in the treatment of colorectal liver metastasis/es <3,5 cm in patients undergoing surgical resection (metastatectomy, segmental liver resection…

A multicenter, open label, phase I / II study to evaluate safety, pharmacokinetics and efficacy of BIBF 1120 in comparison with oral sorafenib for advanced hepatocellular carcinoma patients.

To evaluate the efficacy and safety of BIBF 1120 in HCC patients without prior systemic treatment as compared to Sorafenib.

Radioactive holmium microspheres for the treatment of patients with unresectable liver metastases; a single center, interventional, non-randomized, phase II efficacy (HEPAR II) trial.

Primary objective:To determine target lesions tumour response.Secondary objectives:* To determine overall tumour response.* To determine the liver specific progression-free survival.* To determine non-liver specific progression-free survival.* To…

Reperfusion-induced self-antigen excretion (RISE) following major liver resection

To investigate the release of damage-associated molecular patterns (DAMPs) following major hepatic resection with or without VIO and to correlate the outcomes to the acute inflammatory response and clinical parameters for hepatocellular damage.

The Orange III trial: Optimised recovery with Movicol preoperatively within an enhanced recovery programme, a randomised controlled trial

The aim of this study is to accelerate recovery after liver surgery by enhancing intestinal passage through the preoperative use of Movicol®.

Retrograde in situ hypothermic perfusion of the liver during right hemihepatectomy

To reduce intraoperative blood loss and enhance tolerance of the FRL to I/R injury during right hemihepatectomy under vascular exclusion by means of in situ hypothermic perfusion with retrograde outflow (R-IHP) of the FRL.

Procalcitonin to guide obtaining bloodcultures in the ICU.

The trial aims to investigate whether procalcitonin measurements can reduce the amount of blood cultures in the ICU safely and cost-effectively.

A randomized, double-blind, placebo-controlled PK/PD guided, phase I study in healthy volunteers given escalating, single intravenous doses of NI-0101 in the absence or presence of a systemic LPS challenge.

Part 1:- To assess tolerability, safety and PK of escalating single Intravenous (IV) doses of NI-0101 in healthy volunteers with the aim of covering a wide range of plasma concentrations up to those theoretically reflecting a potential therapeutic…

Fluorescence in situ hybridization in the early diagnosis of cholangiocarcinoma in patients with primary sclerosing cholangitis

To evaluate the outcome of FISH testing with a set of biomarkers with regard to the prognostic value and the diagnostic accuracy for both sporadic cholangiocarcinoma and PSC related cholangiocarcinoma. Subsequently we want to develop a valid…

Validation of diffusion weighted imaging in liver lesions

Determine normal ADC values and the reproducibility of the ADC values in normal liver tissue and colorectal liver metastases in a multicentre trial. Determine the effect of lesion volume on reproducibility of the ADC values.

The role of the microbiota in the systemic immune response

To investigate the role of the gut microbiota in the systemic priming of immune effector cells

Functional magnetic resonance imaging of pancreatic cancer: a feasibility and reproducibility study

To optimize DCE-MRI, T2* MRI and DWI in pancreatic cancer at 3T and investigate its reproducibility.

Protocol ALL-11:Treatment study protocol of the Dutch Childhood Oncology Group for children and adolescents (1-19 year) with newly diagnosed acute lymphoblastic leukemia

1. To improve the overall outcome as compared to the previous protocols of the DCOG, especially ALL-9 and ALL-10.This is aimed for by decreasing therapy for part of the patients (TEL/AML1, Down syndrome, PPR only), increasing therapy for IKZF1…