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Preoperative short-term radiotherapy for primary resectable rectal cancer:
Accelerated once daily (5x5Gy)
versus
accelerated hyperfractionated twice daily (12x2,5Gy b.i.d.)
(ONCE-TWICE trial)
A phase II single-blinded multi-institutional randomised study

The objective of this prospective randomised trial is to test the hypothesis that hyperfractionated short course preoperative radiotherapy (12 x 2.5 Gy twice daily) leads to less radiation-induced bowel toxicity compared to the standard…

CROSSFIRE trial: Crossatlantic Randomized controlled trial comparing Outcome in Survival after Systemic plus Focal therapy for Inoperable pancreatic carcinoma: Radiotherapy versus irreversible Electroporation

The objective of this study is to compare the efficacy of chemotherapy and IRE (experimental arm) to the efficacy of chemotherapy and radiation (control arm) in patients with locally advanced, non-resectable, non-metastasized, pancreatic cancer.