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Paravertebral catheter versus Epidural analgesia in Minimally Invasive Esophageal Resection: a randomized controlled multicenter trial (PEPMEN trial)

To compare paravertebral catheter versus epidural analgesia regarding the quality of recovery in patients undergoing minimally invasive esophagectomy.

Personalized prediction and regulation of 5-FU exposure

Primary objective:To determine the percentage of the patients that achieve optimal 5-FU exposure within two dose cycles of 5-FU, which is defined by an AUC target of 5-FU between 20 and 30 mg h/L or dose limiting toxicity.Secondary objectives:-To…

An open label, multi-center nilotinib roll-over protocol for patients who have completed a previous Novartis-sponsored nilotinib study and are judged by the investigator to benefit from continued nilotinib treatment

The purpose of this study is to allow continued use of nilotinib in patients who are on nilotinib treatment in a Novartis-sponsored, Oncology Clinical Development & Medical Affairs (CD&MA) study and are benefiting from the treatment…

The effect of pelvic floor muscle training on bowel symptoms after low anterior resection for rectal cancer.

The proportion of successful patients, defined as an improvement in LARS category, will be 25% larger in the experimental group than in the control group (in which 10 % improvement is assumed).