58 results
We hypothesize a lung*protective mechanical ventilation using lower tidal volumes during general anesthesia for minimally invasive transthoracic esophagectomy to protect against postoperative pulmonary complications in patients undergoing minimally…
1. To determine the optimal acquisition technique for USPIO enhanced MRI (without contrast injection), DCE (without contrast injection) and DWI and T2* MRI of esophageal cancer in terms of signal-to-noise ratio, time resolution and spatial…
The primary aim of the study is to assess whether DWI, DCE-MRI, T2*, and 18F-HX4-PET/CT predict overall survival in patients with pancreatic cancer treated with surgery and adjuvant chemotherapy or with neoadjuvant radiochemotherapy, surgery and…
The primary objective of the research is to measure the effect of a 3 week prehabilitation program on the postoperative complications in patients with an anaerobic threshold of <11 ml/kg/min who*ll undergo elective coloretal surgery for…
To compare the protein profile of Barrett*s mucosa with and without early neoplasia in ER specimens in epithelial and stroma aiming to identify a biomarker indicating presence of early neoplasia in BE.
Objective of this study is to determine the prevalence of vitamin B12 deficiency among patients who underwent esophagectomy with GTR. The following specific research questions heve been defined:- What is the prevalence of vitamin B12 deficiency in…
The effect of radiotherapy on glucose metabolism in patients with rectal cancer; a feasibility study
Primary objective:Effect of preoperative radiotherapy on insulin resistance in rectal cancer patients.Secondary objectives:Effect of preoperative radiotherapy on plasma oxidative stress parameters.
Primary Objective:- To determine the incidence of EPI in pancreatic cancer.Secondary Objectives are: 1. To identify the predictive factors for the development of EPI in pancreatic cancer.2. To evaluate the occurrence of nutritional deficiencies in…
The effect of the dipeptide alanyl-glutamine, intravenously or enterally and perioperatively given, on postoperative insulin resistance in colon cancer patients.
To determine whether surgery induces changes in the liver vasculature of patients with colorectal cancer.
To investigate whether stem cell sparing radiotherapy results in a lower risk of dry-mouth syndrome than current standard treatment technique.
1) Study the chemopreventive potential of 5-ASA and UDCA in UC by evaluating the effect of treatment on ACF number, size and rate of dysplasia, relative to the placebo group. 2) Gain mechanistic insight into the chemopreventive properties of 5-ASA…
Assess the feasibility of preoperative treatment with pertuzumab and trastuzumab combined with preoperative chemoradiation (carboplatin, paclitaxel and radiation) in terms of withdrawal rate from surgery
To determine which costimulatory and co-inhibitory molecules are expressed on tumor-infiltrating lymphocytes (TIL) derived from patients with CRC (including metastasized CRC), and to study the effects of targeting these molecules on their function…
This is a pilot pretest-posttest intervention study to first test feasibility of an intensive, personalized, integrated training program consisting of disease-specific education, in combination with physical exercise and mental coaching in order to…
The feasibility of preparing untreated esophageal adenocarcinoma endoscopic biopsies towards DNA/RNA samples suitable for next-generation sequencing.
To evaluate the feasibility to assess treatment response on radiochemotherapy for locally advanced rectal cancer by repeated anatomical and functional MRI and FDG-PET.
To determine the reproducibility for quantitative analysis of MRI with contrast en diffusion weighted MRI (DWI) if abdominal malignant tumors.
The primary objective of this second phase study is to estimate the occurrence of anastomotic leakage when the C-seal is used.Secondary objectives are:* Feasibility of applying the C-seal, especially considering the improved attachement to the…
To quantify rectal tumour motion using (cine-)MRI and to correlate this motion with rectal wall movement in order to check the feasibility for CBCT controlled dose escalation for rectal cancer.