111 results
Study phase 1: In patients with BO undergoing work-up endoscopy for early neoplasia, we aim to develop a classification to evaluate fluorescence spectroscopy of neoplastic and non-neoplastic lesions in Barrett epithelium, as used in phase 2.Study…
To compare a new endoscopic brush device with conventional brush cytology and compare the amount of cells obtained by the two different brushes
We want to estimate the additional value of perfusion CT over the 4 phase contrast CT. Furthermore, we want to correlate measurements of perfusion CT (parameters) to histopathological properties of the tumor.
1. to investigate the WavSTAT optical biopsy system by collecting fluorescence spectra of non-dysplastic and dysplastic Barrett mucosa and correlate these to the histology. The integrated optical/physical biopsy forceps will ensure spot-on…
Primary Objective: To evaluate whether a single intravenous alfentanil bolus (7.5 mcg/kg) has a clinically significant analgesic effect in clinical patients who undergo an elective CT-colonography compared to placebo. We have defined a clinically…
The overall objective is to assess the effectiveness of treating patients with corticosteroids prior to surveillance in order to diminish the pitfall of active inflammation.
The aim of this study is to determine whether chromoendoscopy, including polypectomy of all detected lesions, reduces the development of colorectal neoplasia in Lynch syndrome patients at follow-up endoscopy.
Primary Objective: Description of the 1-year overall survival after chemo-radiation therapy with or without panitumumab in irresectable carcinoma of the oesophagus. The control arm is used to validate whether the historical cohort used for…
The objective for this study is to investigate different types of techniques and strategies, in order to optimize scan-parameters, image quality and patient acceptance in Magnetic Resonance Colonography.
The primary objective is to determine the feasibility of the in vivo sentinel node procedure in patients with colon carcinoma, during open and minimal invasive surgery.The secondary objective of the study is awareness and knowledge of (non)sentinel…
Primary objective: to investigate the day-to-day shape variation of the CTV in rectal cancer patients in order to determine adequate PTV margins for radiotherapy treatment.Secondary objectives: to investigate the influence of bladder and rectal…
Primary: Evaluate the ergonomics and function of the imaging system - the NIRF imaging system should not interfere with the standard esophagus resection and lymphadenectomy procedure by the surgeon while detection of indocyanine green (ICG) takes…
To investigate the diagnostic accuracy and burden of MR colonography at 3.0 Tesla, using limited bowel preparation and CO2 for colonic distension.
In patients with BO undergoing surveillance or work-up endoscopy for early neoplasia, we aim to evaluate if EQMI, consisting of ETMI combined with pCLE, increases the accurary of detecting early neoplasia (study phase 1). In addition, we aim to…
The aim of this study is to investigate whether DWIBS is appropriate for colorectal cancer screening.
1. Study the overall miss rate of polyps detected with the third eye retroscope compared to standard colonoscopy.2. Study the overall miss rate of adenoma detected with the third eye retroscope compared to standard colonoscopy.3. Analyze the time…
To compare the yield of autofluorescence guided targeted biopsy versus four-quadrant random biopsy in the evaluation of patients with known occult neoplastic lesions in Barrett*s Esophagus.
To investigate if there is a correlation between tumor perfusion and oxygenation, and downgrading of the tumor. This in order to better select those patient upfront, who will truely benifit from adjuvant radiation therapy.
To investigate what CTC iodine tagging-only bowel preparation gives a high image quality and readability of the CTC together with a high patient acceptance.
Primary, to determine whether staining of the gastric mucosa increases the number of detected (pre)malignant foci of diffuse type gastric cancer, in individuals from families with FDGC as well as dysplastic, adenomatous and early intestinal cancers…