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SURVive: investigating new imaging criteria for non-operative treatment following neoadjuvant chemoradiation in rectal cancer patients

Evaluation of the feasibility of the combination of (DW-)MRI and digital FDG-PET/CT for prediction of response to chemoradiation therapy.

Fluorescence Molecular Endoscopy of locally advanced esophageal carcinoma using bevacizumab-800CW to evaluate dose response after neoadjuvant chemoradiotherapy: a single-center feasibility study.

The primary objective of this study is to determine the safety and feasibility of fluorescence molecular endoscopy using the fluorescent tracer bevacizumab-800CW for identification of pathological complete response after neoadjuvant…

A pilot study to assess the safety and feasibility of fluorescent sentinel lymph node identification in colon carcinoma using submucosal bevacizumab-800CW

The primary outcome parameters are identification rate of SLN(s) or lymph node metastases with bevacizumab-800CW, defined as the number of patients in which a SLN or lymph node metastasis was detected due to fluorescence during surgery and/or…

Concordance in MRI and Pathology Diagnosis of Extranodal Tumour Deposits

To prove the accuracy of MRI/CT diagnosis of tumour deposits and their adverse effect on prognosis.

The ARGOS project: Real-time assessment of Barrett neoplasia using computer aided detection. A pilot study

The aim of this pilot study is to interrogate the feasibility of the workflow, using this image-based CAD system real-time in the endoscopy suite.

Catch the cancer;
towards a cfDNA-based test for colorectal cancer screening

The primary objective of the CATCA-study is to develop a cfDNA based screening/surveillance tool for colorectal adenoma and cancer, both in the setting of the national CRC screening program and in the surveillance of LS carriers. Additionally, we…

Optimalisation of exocrine pancreatic insufficiency and pancreatic enzyme replacement therapy.

Primary aim of this study is to validate easy and reliable tests to detect EPI in patients after gastrointestinal surgery. The 72-hour faecal fat quantification (gold standard), will be compared with a shortened version of 24-hours, the FET and 13C-…

Pretreatment upper-GI cancer organoid models for tailoring neoadjuvant treatment regimens

We aim to grow organoids from a large series of patients with gastric or esophageal cancer. The effect of the standard regimens of chemotherapy of radiotherapy is assessed on the organoids in vitro and correlated to the pathological response of the…

Safety and feasibility of wide-area trans-epithelial sampling for detecting residual disease after neoadjuvant chemoradiotherapy for esophageal cancer

The objective of this study is to assess the safety and feasibility of WATS for esophageal sampling after nCRT in patient with esophageal cancer.

Endoscope CRC cohort: Development and evaluation of diagnostic and prognostic biomarker profiles for colorectal cancer and premalignant lesions

The primary objectives of this study are: to identify and validate non-invasive biomarkers for pre-malignant and malignant colonic lesions, which can be used to aid CRC screening and improve polyp surveillance, with maximum true-negative rates, but…

[68Ga]Ga-FAPI-46 positron emission tomography in pancreaticobiliary cancers: a pharmacokinetics, repeatability and diagnostic accuracy study.

This study has been transitioned to CTIS with ID 2024-516486-36-00 check the CTIS register for the current data. Part A: To acquire an optimal pharmacokinetic model of [68Ga]Ga-FAPI-46 by which simplified methods to quantify [68Ga]Ga-FAPI-46 PET…

Pancreatic cancer surveillance in CDKN2A and other high risk mutation carriers

The primary objective is to study if PC surveillance in individuals with a CDKN2A or other high risk mutations leads to an increase of 5-year survival rate, as compared to PC in the general population. Secondary objectives are: (1) to study long-…

A combination of pre-screening for DPD deficiency by genotyping/phenotyping methods and pharmacokinetics-guided dosing of 5-FU for precision treatment to prevent severe toxicity in gastrointestinal cancer patients.

The primary objective of this study is to investigate the clearance of 5-FU for the 4 most common DPYD gene variants compared to the clearance of 5-FU in DPYD wild-type patients. The secondary objectives of this study are to determine the toxicity…

Multicenter, open-label, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcino-embryonic antigen (CEA) monoclonal antibody, for locally advanced or recurrent rectal cancer patients undergoing curative surgery.

This study has been transitioned to CTIS with ID 2024-510768-21-00 check the CTIS register for the current data. This study aims to investigate if fluorescence guided surgery performed with SGM-101 can improve R0 resection rates and allows to find…

Dedicated MR imaging vs surgical staging of peritoneal carcinomatosis in colorectal cancer patients; a randomized multicenter trial

Our goal is to perform a multicenter randomized study to compare a less invasive diagnostic workup ARM A (with MRI and surgical inspection reserved for borderline operable cases on MRI) to the standard diagnostic workup (ARM B, without MRI, with…

COlon Capsule Endoscopy as an AlterNative for CT-colonography in Colorectal Cancer Screening

The aim of this study will be to evaluate the applicability of using CCE in the Dutch colorectal cancer screening programme in participants with positive FIT outcomes who have contra-indications for subsequent colonoscopy, who have a prior…

Adjuvant chemotherapy for prevention of recurrence in patients with detectable ctDNA after surgery in high-risk rectal cancer.

This study has been transitioned to CTIS with ID 2024-517700-12-00 check the CTIS register for the current data. To improve disease-free survival in patients with high-risk rectal cancer by treating these patients with adjuvant chemotherapy in case…

Evaluation of a real-time computer aided detection and diagnosis system of Barrett's neoplasia during live endoscopic procedures: A multicenter prospective study

The aim of this study is to assess the performance of our CADe/CADx system in detecting and diagnosing Barrett neoplasia during live endoscopic procedures.

A performance study of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen monoclonal antibody for fluorescence-guided imaging to determine local extent and resectability during surgical resection of pancreatic ductal adenocarcinoma after neoadjuvant treatment

This study has been transitioned to CTIS with ID 2023-510481-27-00 check the CTIS register for the current data. This study evaluates the yield of NIR-Fluorescence imaging as additional surgical-tool for visualization and assessment of local extent…

TOwards Personalized multi-modality esophageal cancer treatment using machine learning-based Quantitative MRI

Primary:Sub-study I:- To develop high-quality fast quantitative MRI protocol for multi-contrast imaging of tumour pathophysiology at 3T in esophageal cancer patientsSub-study II:- To determine inter- & intra-session test-retest…