32 results
Primary Objectives:1. To compare protein synthesis rate of the tumour and normal pancreas between cachectic and non-cachectic patients with pancreatic cancer.Secondary Objective(s):1. To compare protein synthesis rate of liver, intestinal, adipose…
Lynch-related tumors mostly develop in the ascending right side of the colon (70-85%). Strikingly, it was recently discovered that dense bacterial biofilms and invasive bacteria occur in the colonic mucosa of 87% of right-sided colorectal cancer (…
To analyze the gut microbiome in relation to response and toxicity in a prospective cohort of patients with newly diagnosed metastasized or irresectable colorectal carcinoma treated with standard systemic therapy.
To test the hypothesis that vedolizumab has chemopreventive properties with regard to colorectal neoplasia in the high-risk group of patients with PSC/IBD.
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
The RADAR-PANC trial is designed to investigate whether a standardized surveillance strategy with serial tumor marker testing and routine imaging improves the overall survival in patients after radical resection for pancreatic ductal adenocarcinoma…
The primary aim of this study is to compare intrinsic pathway activation between cancer patients with acute VTE and those without VTE. Intrinsic pathway activation will be assessed by measuring coagulation factor complexes with their natural…
To collect biomaterials (peripheral blood, DNA, serum, faeces and intestinal biopsies from IBD patients with dysplastic lesions in the colon to allow research into the immunological pathways leading to dysplasia development.
To investigate whether recently identified patient-specific factors can predict the occurrence of anastomotic leakage in patients undergoing elective surgery for colorectal cancer. Secondary: to develop a predictive model/diagnostic algorithm for…
To establish the diagnostic and predictive value of different biomarkers in patients with pancreatic cancer by the investigation of:- Mutated ct-DNA levels in pancreatic juice and blood.- Chromosomal instability in pancreatic juice and blood.- Pro-…
1. To determine the predictive value of frailty characteristics for loss of HRQL in elderly patients with non-metastatic CRC.2. To develop an AGE-CRC score, a prediction model for loss of HRQL in elderly patients with CRC based on comorbidity, risk…
To develop a prediction model for EOCRC patients that estimates the risk of having low HRQoL one year after inclusion based on a comprehensive set of predictors including patient characteristics, disease and treatment factors, lifestyle variables…