31 results
Primary objectives:To validate the concept that ex vivo organoid response correlates to in vivo response to standard treatment in mCRC patients on a metastasis level.Secondary objectives:• Relate organoid results to response to treatment on a…
Establish the immunogenicity of tumor organoids in vitro
To validate promising circulating predictive biomarkers for FOLFIRINOX response in patients with PDAC, found in our previous pilot cohort (iKnowIT study, NL65025.078.18, MEC-2018-087) and to generate a biobank of blood samples to investigate future…
We aim to determine the validity of the steep ramp test as practical performance-based aerobic capacity test in patients undergoing elective colorectal resection by correlating the tests* scores with the ventilatory anaerobic threshold and oxygen…
The primary objective is to investigate the concordance between the Endosign test and EGD by an expert endoscopist for detecting dysplasia and/or EAC in a high-risk category of ULSBE patients. Secondary objectives are to determine the acceptability…
This study will evaluate feasibility in terms of adherence and compliance to, patient satisfaction with, and recruitment and retention of, an exercise intervention during CRT in advanced HNC patients. Secondary objectives are to obtain preliminary…
To develop a model that predicts the probability of pathologic complete response to nCRT in esophageal cancer, by integrating diffusion weighted magnetic resonance imaging (DW-MRI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI)…
The aim of the RADICES study is to investigate the effects of a 12-week exercise and nutrition intervention for patients with metastatic oesophageal or gastric cancer. The intervention will be completely tailored to the condition and nutritional…
To investigate whether there are differences in single nucleotide polymorphism*s (SNPs), circulating tumor DNA (ctDNA), micro RNA (miRNA) and immune profiles between responders and non-responders to FOLFIRINOX chemotherapy and between patients who…
The primary objective of this study is to investigate the association between changes of lean body mass and overall grade 2-4 toxicity during adjuvant chemotherapy in colon (or rectal) cancer patients.
To determine the local and systemic immune profile, with emphasis on T lymphocytes, in pancreatic cancer patients; and monitor how these immune profiles are affected by treatment for individual patients.