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A randomized, open-label, multi-center phase II study to compare AUY922 with docetaxel or irinotecan in adult patients with advanced gastric cancer, who have progressed after one line of chemotherapy

Primary objective: * To assess the treatment effect on progression-free survival in patients who receive AUY922 on a once-weekly schedule versus patients who receive docetaxel or irinotecanSecondary Objectives* To estimate the overall survival…

A Phase 1 Study to Evaluate the Safety, Tolerability and Efficacy of MK-8353 Combination Therapies in Subjects With Advanced Solid Tumors

To determine the dose-limiting toxicities (DLTs) and maximum tolerated dose (MTD) of MK-8353 administered orally in combination with other agents to adult subjects with advanced tumors and to determine the recommended Phase 2 dose (RPTD) of MK-8353…

A multi-center, randomized, open-label, mechanism of action trial on the biological effects of the therapeutic cancer vaccine Stimuvax® (L-BLP25) in rectal cancer subjects undergoing neoadjuvant chemoradiotherapy

The primary objective of the trial is to evaluate whether L-BLP25 administered as weekly subcutaneous vaccinations with or without pretreatment with intravenous cyclophosphamide (CPA) induces a change in immune response parameters (ELISpot against…

A Phase 2 Study of a Human Anti-PDGFRα Monoclonal Antibody (IMC-3G3) in Previously Treated Patients with Unresectable and/or Metastatic Gastrointestinal Stromal Tumors (GIST)

The primary objective of this study is to evaluate the tumor response of stable disease (SD), partial response, or complete response at at 12 weeks (according to RECIST 1.1 criteria) in two separate cohorts representing molecularly distinct subsets…

Vaccination with HA-1 peptide in patients showing minimal residual disease or mixed chimerism after allogeneic stem cell transplantation and donor lymphocyte infusion.

To determine the safety and toxicity of administration of HA-1 peptide vaccine in HLA-A2 and HA-1 positive patients who had undergone allogeneic stem cell transplantation from a HLA-A2 positive, HA-1 negative donor.To evaluate whether an immunologic…

A Pilot Study to monitor changes in Rectum Carcinoma during Radiotherapy with multi-parametric MRI

This study aims to be a pilot study for the treatment of rectum carcinoma on the MRL. A dataset will be collected which allows for an estimation of the anatomical and geometrical variation of the GTV and of the variation of the functional response…

Feasibility study of intratumoral gold marker placement and cone beam CT for
image- guided radiotherapy in rectal cancer

The aim of this study is to establish the use of VisicoilTM fiducial markers and kV cone beam imaging for image guided radiotherapy. Our goal is to develop an accurate technique to correct for inter-fraction organ motion based on fiducial marker…

Long-term follow-up after RFA with or without prior EMR for early Barrett's neoplasia

The aim of this study is to answer the question if RFA is an effective treatment modality in the long term, for patients with Barrett's esophagus containing HGIN or EC.

Repeat CT scans to determine shape variation during radiotherapy of the esophagus in esophageal cancer patients: ReShape study

Primary objective: to investigate the intra- and interfraction motility of the CTV (the primary tumor as well as any affected celiac lymph nodes) in radiotherapy for esophageal cancer, and to determine adequate CTV-ITV margins.Secondary objective:…

Preliminary effectiveness and feasibility of two pre-operative Inspiratory Muscle Training (IMT) interventions in patients undergoing oesophageal resection

Main objective is to examine the preliminary effectiveness of preoperative IMT high-intensity in patients undergoing oesophagus resection on postoperative pulmonary complications, inspiratory muscle strength/endurance and IC stay compared to…

Phase 1b Multiple Ascending Dose Study of BMS-833923 (XL139) Administered in Combination with Cisplatin and Capecitabine as First-Line Therapy in Patients with Inoperable Metastatic Gastric, Gastroesophageal, or Esophageal Adenocarcinomas

To establish the MaximumTolerated Dose, Dose Limiting Toxicities, and the safety profile of BMS-833923 administered in combination with cisplatin and capecitabine as first-line therapy. To describe preliminary evidence of tumor response as measured…

Value of PET-CT in Radiation Treatment Planning for Patients with Esophageal Cancer (RESPECT-shadow-study)

The present study is intended to prospectively evaluate the validity of PET/CT with regard to target volume definition by assessing the incidence of locoregional recurrences outside the CTV among patients with esophageal cancer.The hypothesis to be…

Phase I study of radiotherapy dose escalation on the 18F-FDG-PET avid region of the primary tumor in locally advanced oropharynx and oral cavity tumors eligible for concurrent chemoradiation.

Primary objective:• To determine the maximum tolerated dose of radiation to the FDG-PET avid subvolume within the GTV of the primary tumor. Secondary objectives:• To determine the incidence and severity of acute and late toxicity of dose escalation…

Traditional invasive vs. minimally invasive esophagectomy

Optimalisation of the surgical treatment of esophageal cancer.

Phase I study: determining toxicity and immunity of the p53 synthetic long peptides vaccine combined with Interferon-alfa in patients treated for colorectal cancer

Primary objectives of the study are to assess whether the administration of p53-SLP together with the local administration of IFNα is safe and able to induce a strong (directly ex-vivo detectable) p53-specific CD4+ T-cell response. Secondary…

Prospective randomized comparison of EMR versus EMR followed by photodynamic therapy for the treatment of early barrett's cancer.

In this project we will evaluate the added value of PDT after complete EMR in patients with prior HGD and EC in Barrett*s esophagus.

A Multicenter Phase II Study of Neoadjuvant Docetaxel, Cisplatin and Capecitabine and Protocolized Surgery in Resectable Gastric Cancer
An IKZ-based phase II feasibility study

This study investigates the feasibility role of neoadjuvant chemotherapy, consisting of docetaxel (Taxotere), cisplatin and capecitabine (Xeloda) (TCX), and protocolized surgery in localized and/or locally advanced resectable gastric cancer (D1extra…

A phase I/II trial testing nelfinavir, an inhibitor of Akt signaling, in combination with preoperative chemoradiotherapy in patients with locally advanced rectal cancer

The aim is to study safety and activity of nelfinavir, added to standard chemoradiotherapy (26x1.8 Gy and capecitabine 825 mg/m2 BID) in patients with locally advanced rectal cancer. Furthermore analysis of the effect of nelfinavir combined with…

A Comparison of Two Expandable Metal Stents for the Palliation of Malignant Esophageal Disease

To compare the conventional Ultraflex® Stent with the newly designed Evolution® Controlled Release Stent for the palliation of patients with malignant esophageal disease.

A randomized, open-label, multi-center study to evaluate the efficacy of nilotinib versus best supportive care with or without a tyrosine kinase inhibitor (investigator's choice) in adult patients with gastrointestinal stromal tumors resistant to both imatinib and sunitinib.

Primary* To evaluate whether the efficacy of nilotinib is superior to the control arm (as measured by progression free survivalSecondary* To compare the response rate, and time to response, duration of response, and time to tumor progression of…