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A Phase I Study Assessing the Safety and Performance of SGM-101, a Fluorochrome-Labeled Anti-Carcinoembryonic Antigen Monoclonal Antibody for the Intraoperative Detection of Neoplastic Lesions in Patients with Cancer of the Colorectum or Pancreas

1. To assess safety of different doses of a single iv injection of SGM-1012. To assess the performance of SGM-101 in the intraoperative detection of colorectal or pancreas cancer by:a. Tumor-to-background ratio (TBR);b. Concordance between…

A Phase IIb, Open Label Study for the Detection of Dysplastic Colorectal Polyps during Colonoscopy after EMI-137 Injection in Patients with High Suspicion of Colorectal Cancer.

Primary ObjectivesTo assess the efficacy of 0.13mg/kg EMI-137 IV injection to detect lesions during colonoscopy, in subjects at high suspicion of developing colorectal cancer by:- Comparing the number of pathological lesions detected with WL with…

In vivo identification of rectum and colon carcinoma during surgery using optical spectroscopy techniques

The goal of this pilot study is to calculate the sensitivity and specificity for discriminating tumour and benign tissues in vivo in colorectal cancer patients based on optical spectroscopy measurements. The secondary goal of this study is to…

Added value of digital PET/CT in (re)staging patients with pancreatic cancer

to determine the diagnostic value of digital PET/CT as a staging and restaging imaging modality, as compared with ceCT and Ca 19.9, in patients with (borderline) resectable pancreatic cancer

Sentinel lymph node identification in colon cancer using the hybrid tracer ICG- 99mTc-nanocoll

Aim of the study is to develop an intraoperative technique for SLN mapping in colon cancer which is suitably in daily practice in colon surgery in an average hospital setting.

Repeated magnetic resonance imaging in esophageal cancer for adaptive radiation treatment planning during chemoradiotherapy.

Primary objective:- To develop a patient-specific adaptive radiotherapy planning strategy using MRI with more precise target coverage and critical organ sparing by safely reducing treatment margins for resectable esophageal cancer irradiation.…

MAGENTIQ-COLO CSC study
Evaluation of the diagnostic performance of computer-aided polyp size classification of the MAGENTIQ-COLO during real-time colonoscopy

The primary objective of the study is to assess the diagnostic performance of the endoscopist performing a MAGENTIQ-COLO CADx-assisted colonoscopy to classify polyps as diminutive (<=5mm) or non-diminutive (>5mm) compared to size…

Using Diffuse Reflectance Spectroscopy Probes to conduct Optical Measurements during Surgery for Colorectal Cancer

To assess the practical usability of our DRS probes for the detection of positive resection margins in colorectal cancer surgery - specifically whether they can be used in the confined surgical workfield in the lower pelvis - as well as the…

Measurement of oxidation reduction potential in the colon using an ingestible sensor in patients with ulcerative colitis (UC) and colorectal cancer (CRC)

Measurement of intestinal oxidation-reduction potential using a smart sensing ingestible and its relation to active UC and CRC.

High-resolution colon manometry in patients suffering from LARS symptoms after surgery for rectal cancer.

The rationale of this study was to investigate the alteration of colonic motor patterns in the early postoperative stage and between patients with no or minor LARS-symptoms (LARS-score < 30) compared to patients experiencing major LARS…