26 results
To determine whether micellar curcumin is able to restore functional lymphocytes in pancreatic cancer patients with stable disease after standard of care treatment.
The aim of the study is to compare transthoracic esophagectomy versus transhiatal extended gastrectomy in patients with GEJ type II tumors. It is hypothesized that esophagectomy allows for a higher rate of radical resections and a more complete…
The aim is to investigate the effect of a multimodal prehabilitation and rehabilitation program in frail patients of 70 years or older, undergoing elective surgery for non-metastatic CRC on1. One-year mortality 2. Postoperative complications,…
The aim of this study is to investigate the feasibility and safety of a 23-hour accelerated ERAS protocol for patients undergoing colorectal surgery. In this accelerated ERAS protocol, patients undergoing colorectal surgery will be discharged within…
To investigate whether a standardized multidisciplinary treatment of rectal cancer patients with enlarged lateral lymph nodes will decrease the amount of local recurrences. Secondary outcomes are morbidity, quality of life and functional outcomes.
The main goal of the current randomized study is to investigate if SABR may relieve tumor-related symptoms, improve the quality of life and potentially prolong survival in this frail patient group compared to best supportive care, which is the…
Primary objective:To characterize safety and tolerability of each treatment arm tested and identify recommended doses (RD) and regimens for future studies, by assessing the incidence and severity of AEs and SAEs; including changes in laboratory…
This study has been transitioned to CTIS with ID 2023-503312-32-00 check the CTIS register for the current data. Possibly, outcomes of treatment of irresectable squamous cell carcinoma of the esophagus can be improved by adding bintrafusp alfa to…
The main objective of this study is to investigate whether quality of life can be improved by personalised and timed guidance, and/or use of the peer-support platform; as provided by a patient-centred mobile application.
The aim of this study will be to evaluate the applicability of using CCE in the Dutch colorectal cancer screening programme in participants with positive FIT outcomes who have contra-indications for subsequent colonoscopy, who have a prior…
To assess the added value of a brachytherapy boost after external beam radiotherapy in elderly, frail patients with rectal cancer.
Primary• To evaluate the safety and tolerability of AMG 910 in adult subjects. • To determine the maximum tolerated dose (MTD) and/or recommended phase 2 dose (RP2D)Secondary• To characterize the PK of AMG 910• To evaluate preliminary anti-tumor…
This study has been transitioned to CTIS with ID 2024-515525-28-00 check the CTIS register for the current data. The aim of this study is to prove feasibility of HAIP chemotherapy (floxuridine) in combination with standard systemic chemotherapy…
Primary objective: to investigate how many patients with detectable ctDNA after surgery start with adjuvant chemotherapySecondary objective: to reduce recurrence rate by ctDNA based adjuvant chemotherapy (ACT) in stage II colon cancer (CC) patients…
This pilot study will be performed to determine the feasibility and effectiveness of a multimodal revalidation program prior to and during adjuvant chemotherapy in patients with stage 3 colon carcinoma.
The main objective of this study is to assess the safety of combining Nivolumab with IRE alone and of combining Nivolumab with IRE and CpG .The secondary objectives of this study are : 1) whether the combination of Nivolumab + IRE, or of CpG +…
Phase 2 pilot-study: to examine feasible exercise dosages in patients with mCRC and collect data on preliminary effects on clinical outcomes.Phase 3 trial: to collect data on the efficacy of exercise on 1) chemotherapy dose modifications and 2)…
Primary Objective: Phase I dose escalationThe main objective of the phase I part is to determine safety and the recommended phase II dose (RP2D) of the triple combination.Phase IIThe main objective of the phase II part is to determine efficacy of…
This study has been transitioned to CTIS with ID 2023-509405-77-00 check the CTIS register for the current data. The purpose of this Safety Lead In study is to explore if encorafenib and cetuximab in combination with a chemotherapy regimen (either…
This study has been transitioned to CTIS with ID 2024-512526-28-00 check the CTIS register for the current data. The primary objective of this study is to determine whether the addition of induction chemotherapy to the neoadjuvant treatment of…