70 results
This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…
Primary objective: to explore 18F-FDHT PET/CT as a predictor of response in patients with metastasized CRPC to be treated with enzalutamide. Secondary objective: to explore 18F-FDHT PET/CT as a predictor of clinical survival endpoints in patients…
Main objective of this study is to determine if the [18F]FB-IL2 PET is able to detect a treatment-induced immune response in tumor lesions of patients with metastatic melanoma and if the tumor uptake of the tracer correlates with the number of IL2…
Tumor organoids: feasibility to predict sensitivity to treatment in cancer patients (TUMOROID trial)
• Evaluate the potential of tumor organoid therapy response to predict treatment response in the patient • Design a standardized organoid screening test and propose a test threshold that ensures a high negative predictive value• Establish the…
1. To evaluate the feasibility of 18F-FDG PET/CT, or WB MRI or both to determine metastatic tumour load before and after treatment with Enzalutamide in CRPC patients. 2. To evaluate how these 2 imaging modalities perform compared to traditional…
Primary objective is to determine the absolute uptake (Standardized uptake value (SUV)) and kinetics (time-activity curves) of [18F]dabrafenib in normal brain and brain metastasis. Secondary objectives are to analyze heterogeneity in [18F]dabrafenib…
Primary Objective: Prediction of PCI with DWI MRI, using the surgically determined PCI as the reference standard.Secondary Objective(s): - MR Protocol optimisation- Comparison of the diagnostic performance of DWI-MRI in assessing the PCI with the…
To validate nano-MRI on 7 Tesla with pathological findings.
Primary Objective:-Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:1 *narrow-band imaging*, (NBI)2 *near-infrared indocyanin green imaging*, (ICG)3 *5-aminolevulinic acid fluorescent imaging*, (5…
The aim of the present study is to measure the test-retest reproducibility of DW-MRI in healthy volunteers, in patients with colorectal liver metastases and in patients with malignant lung lesions in a multicenter setting.
Primary Objective: the primary objective of this study is to determine the feasibility of [18F]FDHT PET/CT for in vivo evaluation of bone metastases in prostate cancer. Active locations will be compared with those seen on conventional imaging (bone…
* To stratify cancer patients for participation in clinical trials.
1. To study the safety and feasibility of para-aortic surgical staging in advanced cervical cancer in the Netherlands.2. To provide insight in the possible effectiveness of para-aortic surgical staging in advanced cervical cancer as compared to…
Comparison of CTCs yield by Detektor CANCER01 and Detektor CANCER02. Both product types will be applied to metastatic PC patients within a double application by the use of the same cannula. The results will be compared and analyzed to choose the…
The primary objective for this study is:• To explore the usefulness of [F-18]RGD-K5 PET/CT to predict efficacy or early response toAvastin® (the anti-angiogenesis drug) plus chemotherapy treatment before the full courseof treatment is completedThe…
To compare the diagnostic performance (sensitivity and specificity) of 18F NaF PET/CT in comparising to 99mTc MDP bonescintigraphy in a cohort of patients with newly diagnosed prostate cancer at high risk of developing skeletal metastases and in…
To compare the diagnostic performance of new lymph node staging methods for prostate cancer (dwMRI fused with 18F-Choline PET-CT) with the current gold standard of staging, the extended pelvic lymph node dissection (ELND)
To detect changes in multiple [18F]fluorodeoxyglucose positron emission tomography * computed tomography ([18F]FDG PET-CT) scans in one patient, test-retest variability needs to be determined, to know when an observed difference is due to a true…
Evaluation of the feasibility of sentinel node detection by PET-CT lymphoscintigraphy
The primary objective of this study is to evaluate the ability of PET-MRI to detect LSR during the first year of follow-up after RFA treatment of CRLM as compared with ceCT and PET-CT. Standard reference will be histology (when available) or…