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Inguinal or Ilio-inguinal Lymphadenectomy for Patients With Metastatic Melanoma to Groin Lymph Nodes and no Evidence of Pelvic Disease on PET/CT Scan - A Randomised Phase III Trial (EAGLE FM)

This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…

PET imaging of [18F]dabrafenib distribution and kinetics in brain metastasis.

Primary objective is to determine the absolute uptake (Standardized uptake value (SUV)) and kinetics (time-activity curves) of [18F]dabrafenib in normal brain and brain metastasis. Secondary objectives are to analyze heterogeneity in [18F]dabrafenib…

DWI MR imaging for dedicated staging of patients with peritoneal seeding.

Primary Objective: Prediction of PCI with DWI MRI, using the surgically determined PCI as the reference standard.Secondary Objective(s): - MR Protocol optimisation- Comparison of the diagnostic performance of DWI-MRI in assessing the PCI with the…

Advanced imaging in HIPEC for peritoneal carcinomatosis of colorectal origin; a feasibility study

Primary Objective:-Evaluate tumour detection sensitivity and specificity with the following image enhancement modalities:1 *narrow-band imaging*, (NBI)2 *near-infrared indocyanin green imaging*, (ICG)3 *5-aminolevulinic acid fluorescent imaging*, (5…

Targeted Abdominal Lymph nodE dissections randomized for surgical NavigaTion (TALENT)

To evaluate if navigation assistance results in more successful localization and removal of extra-regional abdominal lymph nodes compared to standard surgery. Extra regional lymph nodes are defined as suspect target lymph nodes outside the standard…

An Open-Label, Multicenter, Global Phase 2 Basket Study of Entrectinib for the Treatment of Patients with Locally Advanced or Metastatic Solid Tumors that Harbor NTRK1/2/3, ROS1, or ALK Gene Rearrangements

This study has been transitioned to CTIS with ID 2023-505034-10-00 check the CTIS register for the current data. To determine the objective response rate of entrectinib, as assessed by BICR, in each patient population basket of solid tumors that…

Validation of Pharmacokinetic and Pharmacodynamic Assays for determination of Nivolumab and Pembrolizumab concentrations, and the occupancy of their target receptor Programmed Death-1 (PD-1) on T-cells

The aim of this study is to develop and validate the ELISA and potential other assays (e.g. LC-MS), in order to measure drug concentration levels. For this, blood and other material will be collected.

Whole Brain Radiotherapy (WBRT) versus Stereotactic Radiosurgery (SRS) for 4 up to 10 brain metastases: a phase III randomized multicenter trial

To determine if SRS is a better palliative treatment than WBRT for patients with 4 up to 10 BM in terms of QOL at 3 months post-radiotherapy.

A Phase 1 Multicenter, Open-label Study to Evaluate the Safety, Pharmacokinetics, Pharmacodynamics, Immunogenicity, and Antitumor Activity of MEDI0562 in Combination with Immune Therapeutic Agents in Adult Subjects with Advanced Solid Tumors

Primary ObjectiveThe primary objective is to assess safety and tolerability, describe the dose limiting toxicities (DLTs), and determine the maximum tolerated dose (MTD) or the maximum administered dose (MAD; in the absence of exceeding the MTD) for…

USPIO- enhanced High Field MRI for restaging lymph node status in rectal cancer: an explorative study

To validate the use of 3 and 7 Tesla nano-MRI in restaging locally advanced rectal cancer by node-to-node matching of the results of nano-MRI with pathology as the gold standard.

Early identification of patients who benefit from palbociclib in addition to letrozole

To evaluate in a feasibility study whether low uptake on FES-PET at baseline is related to non-response to letrozole plus palbociclib treatment.

Towards early identification of response to cabazitaxel in patients with metastasized castrate-resistant prostate cancer: potential of 18F-Choline PET-CT

The main objective of this study is to assess the predictive value of FCH uptake changes as defined with FCH-PET after one cycle of treatment (vs. baseline) to predict clinical response, as defined by PCWG2 criteria, to treatment of mCRPC with…

Accuracy of lymph node imaging in prostate cancer: A prospective cohort study to determine the concordance between two imaging modalities, *Combidex* magnetic resonance imaging (Nano MRI) and 68Ga-PSMA positron emission tomography (PET).

1. To compare the following imaging technologies to the current practice of histology of pelvic lymph node dissection: a. PSMAGa68 PET b. Nano MR Lymphography and an enhanced arterial map (Nano MRL / EAM) to locate the position of the lymph nodes2.…