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Fear of progression in advanced cancer patients with prolonged survival on ongoing cancer treatment in an era of personalized medicine

The aim of this study is to investigate the concept of fear of progression among advanced incurable cancer patients onongoing systemic treatment.

A first-in-human dose-escalation and expansion study with the antibody-drug conjugate
BYON3521 to evaluate the safety, pharmacokinetics and efficacy in patients with c-MET
expressing locally advanced or metastatic solid tumours.

The primary objective of this trial is:• Part 1 (dose-escalation): To evaluate the safety of BYON3521 and to determine the maximum tolerated dose (MTD) and recommended dose for expansion (RDE); • Part 2 (expansion): To evaluate the objective tumour…

GlucoCEST MRI of the brain in healthy volunteers and patients with brain tumours

To develop a protocol for glucoCEST MRI for brain using the MRI of the recently installed fully integrated PET/MRI apparatus at Erasmus MC.

A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis

This study has been transitioned to CTIS with ID 2024-511066-36-00 check the CTIS register for the current data. Double-blind Phase:Primary Objective:To evaluate the efficacy of birtamimab plus standard of care compared to placebo plus standard of…

A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid Tumors

• Determine the maximum tolerated dose (MTD) and/or recommended dose (RD) for further evaluation of XL092 when administered alone and in combination with ICIs to subjects with advanced solid tumors• Evaluate preliminary efficacy of XL092 when…

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination, in patients with advanced solid/metastatic tumours.

Primary objective To investigate the safety and tolerability of CCS1477 as monotherapy and in combination.

A Randomized Phase 3 Study of MRTX849 versus Docetaxel in Patients with Previously Treated Non-Small Cell Lung Cancer with KRAS G12C Mutation

This study has been transitioned to CTIS with ID 2023-507263-19-00 check the CTIS register for the current data. To compare the efficacy of MRTX849 versus docetaxel in patients with NSCLC with KRAS G12C mutation and who have received prior treatment…

Multi-institutional Evaluation of the Cost-effectiveness of PSMA-PET/CT
for the Detection of Pelvic Lymph Node Invasion in Newly Diagnosed Prostate Cancer
Patients

This study has been transitioned to CTIS with ID 2024-518171-59-00 check the CTIS register for the current data. To determine if the use of Prostate-Specific Membrane Antigen Positron Emission Computer Tomography (PSMA PET/CT) as a selection tool…

The ROAD to sustainable medication use: redispensing unused oral anticancer drugs

To determine the waste reduction, net cost savings and environmental impact attained by redispensing oral anticancer drugs that go unused by patients compared with the standard practice of disposal.