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Clinical Performance Study Protocol for Use of VENTANA PD-L1 (SP263) CDx Assay in AstraZeneca Study D798AC00001(eVOLVE-Lung02):
A Phase III, Two-Arm, Parallel, Randomized, Multi-Center, Open-Label, Global Study to Determine the Efficacy of Volrustomig (MEDI5752) Plus Chemotherapy Versus Pembrolizumab Plus Chemotherapy for First-Line Treatment of Patients with Metastatic Non-Small Cell Lung Cancer (mNSCLC) (eVOLVE-Lung02)

The primary objective of the clinical performance study is to demonstrate the clinical performance of VENTANA PD-L1 (SP263) CDx Assay in terms of its ability to identify NSCLC patients who may benefit from treatment with volrustomig plus…

HER Image: 89Zr-DFO* trastuzumab PET in patients with breast cancer - a pilot study

The aim of this study is to investigate in patients with metastatic HER2 positive or HER2-low breast cancer whether a PET scan with a new HER2 tracer ([89Zr] DFO*trastuzumab) accurately depicts all abnormalities and whether ultimately this HER2 PET…

Fluorescence-guided resection Of Colorectal liver metastases Using SGM-101 and Indocyanine GREEN.

To assess the feasibility of simultaneous use of ICG and SGM-101 for intraoperative imaging of colorectal liver metastases.

Clinical Performance Study Plan for use of B7-H4 (A57.1) Clinical Trial Assay for Patient Enrolment Into The Clinical study (D6900C00001), titled *A Phase I/IIa Multi-center, Open-label Master Protocol to Evaluate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary
Antitumor Activity of AZD8205 in Participants with Advanced or Metastatic Solid Malignancies*.

The primary objective of this clinical performance study is to evaluate the effectiveness of the B7-H4 (A57.1) CTA in identifying B7-H4 positive (B7-H4 membrane staining at any intensity in >=25% tumor cells) ovarian, endometrial, biliary…

FDG-PET/CT to reduce the need for sentinel lymph node biopsy in early-stage oral cancer.

In this study, we aim to investigate the possibility of FDG-PET/CT to reduce the number of (positive) SLNB procedures in patients with early stage oral squamous cell carcinoma and a clinically negative neck.

A multicentre randomised open-label phase III study of stereotactic radiosurgery, in addition to standard systemic therapy for patients with metastatic melanoma or newly diagnosed metastatic NSCLC and asymptomatic or oligosymptomatic brain metastases.

The primary objective of the study is to assess the efficacy in terms of CNS-specific PFS ofthe combination of standard systemic treatment plus SRS versus standard systemictreatment alone in patients with newly diagnosed and untreated (except for…

COLLISION RELAPSE trial - Recurrent colorectal liver metastases: repeat local treatment +/- neoadjuvant systemic therapy - a phase III prospective randomized controlled trial

This study has been transitioned to CTIS with ID 2024-515341-41-01 check the CTIS register for the current data. The primary objective is to demonstrate superiority of neoadjuvant systemic therapy followed by repeat local treatment as compared to…

INTRUSION: Unraveling the INTRatUmoral PK/PD relatION for SAR408701

Primary Objective: • To determine whether there is a correlation between intratumoral DM4 exposure and response to treatment, defined as maximal tumor size deviation of the biopsied lesion according to Response Evaluation Criteria In Solid Tumors (…

The long-term impact of immunotherapy and targeted therapy on outcomes in patients with brain metastases

To determine outcomes in long-term surviving brain metastases patients (>=2 years after diagnosis of brain metastases) treated with immunotherapy or targeted therapy.

Sentinel lymph node detection in patients with stage Ib-III melanoma using MultiSpectral Optoacoustic Tomotraphy (MSOT) and IndoCyanine Green (ICG)

Study the concordance rate of SLN identified using MSOT and ICG versus the standard of care with Tc99m and lymphoscintigraphic imaging.

Deuterium Metabolic MRI and [18F]-flourodesoxyglucose Positron Emission Tomography for Assessment of Treatment Response Following Radioembolization of Liver Metastasis; pilot study,

Primary objective: To assess feasability of DMI for intrahepatic tumor detection. Secondary objectives: - Head-to-head comparison between DMI and FDG-PET/CT for intrahepatic tumor detection.- Assessment of requirements for spatial resolution and…