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A FEASIBILITY STUDY OF SGM-101, A FLUOROCHROME-LABELED ANTI-CARCINOEMBRYONIC ANTIGEN MONOCLONAL ANTIBODY FOR THE INTRAOPERATIVE DETECTION OF COLORECTAL BRAIN METASTASES

This study has been transitioned to CTIS with ID 2024-510767-30-00 check the CTIS register for the current data. 1. To determine the feasibility of SGM-101 for intraoperative imaging of colorectal brain metastases - Concordance between fluorescent…

Adoptive TIL therapy with low-dose PEG-IFNa plus nivolumab in metastatic melanoma

The primary endpoint is the evaluation of the safety and toxicity of TIL with nivolumab and, thereafter, the safety and toxicity of the combination of PEG-IFNa, nivolumab plus TIL. Safety and toxicity will be evaluated according to CTCAE 4.0…

A first-in-human dose-escalation and expansion study with the antibody-drug conjugate
BYON3521 to evaluate the safety, pharmacokinetics and efficacy in patients with c-MET
expressing locally advanced or metastatic solid tumours.

The primary objective of this trial is:• Part 1 (dose-escalation): To evaluate the safety of BYON3521 and to determine the maximum tolerated dose (MTD) and recommended dose for expansion (RDE); • Part 2 (expansion): To evaluate the objective tumour…

A prospective randomized study to compare neurocognitive outcome after Stereotactic Radiosurgery or Whole Brain Radiation Therapy for the treatment of multiple brain metastases

Primary Objective Our primary aim is to compare cognitive decline at 3 months, defined as a significant decline (5 point decrease from baseline based on the reliable change index with correction for practice effects) in HVLT-R Total Recall score (…

A PHASE 2, RANDOMIZED, OPEN-LABEL STUDY OF ENCORAFENIB AND CETUXIMAB PLUS
PEMBROLIZUMAB VERSUS PEMBROLIZUMAB ALONE IN PARTICIPANTS WITH PREVIOUSLY UNTREATED BRAF V600E-MUTANT, MSI-H/DMMR METASTATIC COLORECTAL CANCER

This study has been transitioned to CTIS with ID 2024-512119-34-00 check the CTIS register for the current data. Comparing the efficacy of encorafenib and cetuximab plus pembrolizumab (triplet group [group A]) vs. pembrolizumab (control group [group…

Randomized, Open Label Phase 3 study of SAR408701 versus Docetaxel in Previously Treated metastatic Non-Squamous Non-Small Cell Lung Cancer patients with CEACAM5 positive tumors

The primary objectives of this study are to assess if SAR408701 has a better progression free survival and general overall survival compared to docetaxel, and main secondary endpoints are objective response rate, time to deterioration on health…

GlucoCEST MRI of the brain in healthy volunteers and patients with brain tumours

To develop a protocol for glucoCEST MRI for brain using the MRI of the recently installed fully integrated PET/MRI apparatus at Erasmus MC.

COLLISION trial - Colorectal liver metastases: surgery versus thermal ablation - a phase III prospective randomized controlled trial

The primary objective is to prove non-inferiority of thermal ablation compared to hepatic resection in patients with at least one resectable and ablatable CRLM (<=3cm) and no extrahepatic disease.

A Phase Ia/Ib Open Label, Dose-Escalation study of the Safety and Pharmacokinetics of RO7198457 as a Single Agent and in Combination with Atezolizumab in Patients with Locally Advanced or Metastatic Tumors.

Main Objective (EudraCT):To evaluate the safety and tolerability of RO7198457 when administered as a single agent (Phase [Ph] Ia) or in combination with atezolizumab (Ph Ib), with or without prophylactic treatment with corticosteroids, including…

EORTC ILOC study: Phase II of immunotherapy plus local tumor ablation (RFA or stereotactic radiotherapy) in patients with colorectal cancer liver metastases

The primary objective of this proof of concept study will be to investigate whether the combined use of local tumor ablation/radiation plus immunomodulating drugs may induce a significant immune response in patient with incurable liver metastases…

Trial NL87250.000.24

Publication withdrawn by sponsor

ValUe of screening MRI brain in patients with newly diagnosed stage IV non-oncogene addicted non-small cell Lung CANcer - The VULCAN trial

To assess the impact on treatment decision of a screening MRI brain in asymptomatic patients with newly diagnosed stage IV non-oncogene addicted NSCLC, fit for systemic treatment.

Adaptive Fractionation in Online-Adaptive Stereotactic Radiotherapy for Abdominopelvic Lymph Node Oligometastases

Primary: Can the number of online adaptive fractions be reduced by 30%?Secondary: What is the overall survival, local control, and toxicity? What is the movement of the bowel during treatment? Is there added value in re-aligning the patient when…

PRophylactic cerebral Irradiation or active MAgnetic resonance imaging surveillance in small-cell Lung cancer patients

The primary objective is to show that brain MRI surveillance alone is non-inferior in terms of overall survival (OS) to brain MRI surveillance combined with prophylactic cranial irradiation (PCI) for the treatment of small cell lung cancer (SCLC).

Oligometastatic directed radiotherapy for patients with castration resistant prostate cancer.

The aim of the study is to investigate the effect of MDRT to the visible lesions in patients with omCRPC (up to 3 metastases and/or local recurrence) while continuing the ongoing systemic treatment. Progression is based on prostate specific membrane…

A Phase 3, Randomized, Multicenter, Double-Blind, Placebo-Controlled, Efficacy and Safety Study of Birtamimab Plus Standard of Care vs. Placebo Plus Standard of Care in Mayo Stage IV Subjects with Light Chain (AL) Amyloidosis

This study has been transitioned to CTIS with ID 2024-511066-36-00 check the CTIS register for the current data. Double-blind Phase:Primary Objective:To evaluate the efficacy of birtamimab plus standard of care compared to placebo plus standard of…

A Dose-Escalation and Expansion Study of the Safety and Pharmacokinetics of XL092 as Single-Agent and Combination Therapy in Subjects with Inoperable Locally Advanced or Metastatic Solid Tumors

• Determine the maximum tolerated dose (MTD) and/or recommended dose (RD) for further evaluation of XL092 when administered alone and in combination with ICIs to subjects with advanced solid tumors• Evaluate preliminary efficacy of XL092 when…

Detection of tumor tissue in peritoneal metastases of colorectal origin using a VEGF targeted optical fluorescent imaging tracer during diagnostic laparoscopy: a single center phase 1 study

This study has been transitioned to CTIS with ID 2024-517718-13-00 check the CTIS register for the current data. Primary Objectives:To determine the optimal dose of the VEGF-targeting optical agent Bevacizumab-IRDye800CW for an adequate tumor-…

Open-label, multi-cohort, Phase 2 trial, evaluating the efficacy and safety of tusamitamab ravtansine (SAR408701) monotherapy and in combination in patients with CEACAM5-positive advanced solid tumors

The purpose of this multi-cohort study is to assess the safety and efficacy of tusamitamab ravtansine (SAR408701) in mBC and mPAC participants with CEACAM5 positive tumors which are known to be sensitive to taxanes.

An open-label Phase I/IIa study to evaluate the safety and efficacy of CCS1477 as monotherapy and in combination, in patients with advanced solid/metastatic tumours.

Primary objective To investigate the safety and tolerability of CCS1477 as monotherapy and in combination.