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Identification of germline mutations in familial and extremely early-onset urinary bladder cancer

The main objective of this study is to identify rare, high-penetrance germline mutations predisposing to familial and/or early onset UBC.

Explorable study - possible explanation for the reduced risk of urethral recurrence after Hautmann neobladder for bladder cancer.

Objective of this study is to map the possible differences in immunostatus between a urethra in patients with a Hautmann neobladder and a normal urethra in patients without (a history of urogenital) malignancy; to find clues for the decreased risk…

Prospective Bladder Cancer Infrastructure - An infrastructure for observational and interventional bladder cancer research

We propose to set up a bladder cancer infrastructure within the logistic framework of the NCR. Patients with HR-NMIBC, MIBC and mBC will be prospectively recruited for ProBCI with longitudinal assessments from primary diagnosis until death. Main…

UMBRELLA PROTOCOL SIOP-RTSG 2016
Integrated research and guidelines for standardized diagnostics and therapy for paediatric renal tumours

The overall aim of the SIOP 2016 UMBRELLA protocol is to harmonize the clinical relevant standarddiagnostic procedures for all paediatric renal tumours within SIOP and to provide imaging studies andbiomaterial from all of these patients, to find new…

Prevention of VEGF inhibitor-induced toxicity by salt restricton

To prospectively study the effect of salt restriction on the rise in blood pressure in response to anti-cancer treatment with the VEGF inhibitor sunitinib and regorafenib.

The impact of genetic predisposition in pediatric renal cancer: genotypic and phenotypic characterization

1. To determine the frequency of mutations in known and novel pediatric renal cancer predisposing genes.2. To structurally document phenotypic characteristics of children with renal cancer, to optimize genetic counseling and surveillance and…