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Focal Ablative STereotactic RAdiosurgery for Cancers of the Kidney - A Phase II study

The primary objective of this study is to estimate the efficacy of SABR for primary RCC.

A Phase 3, Randomized, Study of Neoadjuvant and Adjuvant Nivolumab Plus bempegaldesleukin (NKTR-214), Versus Nivolumab Alone Versus Standard of Care in Participants with Muscle-Invasive Bladder Cancer (MIBC) Who Are Cisplatin Ineligible

Primary Objectives• To compare the pathologic complete response (pCR) rate of neoadjuvant nivolumab + NKTR-214 to Standard of Care (SOC, no neoadjuvant therapy) in all randomized participants• To compare the event-free survival (EFS) of neoadjuvant…

Confocal Laser Endomicroscopy before transurethral resection for optimizing Bladder Cancer diagnosis and treatment.

Primary objectives: This study is two-fold and, therefore, has two primary objectives:1. Investigating the diagnostic accuracy of CLE (Cystoflex*F probe) during flexible cystoscopy for diagnosis and grading of urothelial carcinoma of the bladder.2.…

UMBRELLA PROTOCOL SIOP-RTSG 2016
Integrated research and guidelines for standardized diagnostics and therapy for paediatric renal tumours

The overall aim of the SIOP 2016 UMBRELLA protocol is to harmonize the clinical relevant standarddiagnostic procedures for all paediatric renal tumours within SIOP and to provide imaging studies andbiomaterial from all of these patients, to find new…

A Randomized, Double-Blind, Controlled Phase 3 Study of Cabozantinib in Combination with Nivolumab and Ipilimumab versus Nivolumab and Ipilimumab in Subjects with Previously Untreated Advanced or Metastatic Renal Cell Carcinoma of Intermediate or Poor Risk

The objective of this study is to evaluate the efficacy and safety of cabozantinib in combination with nivolumab and ipilimumab versus nivolumab and ipilimumab in previously untreated subjects with intermediate- and poor-risk advanced or metastatic…

Radio guided lymph node dissection in oligo metastatic prostate cancer patients

The primary aim of this study is to evaluate the feasibility and safety of In-111-PSMA I&T radio guided surgery in patients diagnosed with prostate cancer who are highly suspected of having pelvic lymph node metastasis based on pre-operative…

Personalizing therapy of urogenital cancer by metastatic tissue Immune profiling, Organoid culture, and NExt genERation sequencing

- To study the success rate of organoid culture from lymph node, visceral and bone metastases in metastasized urogenital cancer and examine which parameters influence the success rate (culture media, biopsy site, cell counts). - To study the…