16 results
This project will first address the hypothesis that dual time-point 18F-FDG PET and DWI improve the discrimination between residual active tumor and inflammatory/necrotic changes after two cycles of R-CHOP in DLBCL / follicular lymphoma grade 3B ,…
Phase Ib:Estimate the maximum tolerated dose (MTD) and/or the recommended phase II dose (RP2D) of AEB071 and everolimus combination therapy inpatients with DLBCLPhase II:Assess the preliminary evidence for anti-tumor activity at R2PD for AEB071 and…
The aim of this pilot study is to investigate which PET tracer (FDG or FLT) is best suited for early PET diagnosis of transformation in patients with low grade NHL
1. We will perform an exploratory study using whole exome sequencing (WES) on SS MALT lymphoma samples to pick up specific gene mutations enriched or exclusively present in salivary MALT lymphoma in SS patients.2 .We will investigate the relation…
At the moment it is unknown which radiomics features are robust against variations in image characteristics. The objective of this study is to check the robustness of radiomics features, and to investigate wheter specific pre- and postprocessing…
The primary objective is to collect liquid biopsy samples of patients with newly diagnosed DLBCL/HGBCL to develop a blood based assay allowing biomarker driven treatment in the future. The secondary objectives are to collect clinical data and pre-…
Objective: Our main objective is to assess in detail risk factors for cardiovascular disease and cardiotoxicity and to compare heart function parameters, vascular parameters and biomarkers associated with cardiovascular function among 5- to 18-year…
This study has been transitioned to CTIS with ID 2024-518422-32-01 check the CTIS register for the current data. Primary objectives: The first primary objective is to study the expression of PD-L1 in normal tissue and lymphoma lesions before CAR T-…
Conducting research into the role of CSF and blood parameters of patients with CNS lymphoma, focused on improving the diagnostics, identification of biomarkers ('liquid biopsy'), and evaluation of therapy effect.
Primary objectives:The objective is to study the distribution of CD8+ T-cells before and after CAR T-cell therapy in the patient by ZED88082A/CED88004S-PET imaging. We will correlate the pretreatment CD8+ T-cell distribution and CD8+ CAR T-cell…
To demonstrate the ability of using non-invasive 31P-MRS to monitor changes of in vivo markers of mitochondrial function in skeletal and cardiac muscles (i.e., skeletal muscle PCr recovery rate constant and cardiac PCr/ATP ratio) in DLBCL patients…
1 - To determine the feasibility of MRD detection using next generation sequencing (NGS) on circulating tumor DNA (ctDNA) from PTLD patients using a gene panel previously used in diffuse large B-cell lymphoma (DLBCL) 2 - To explore the mutational…
Primary objective:• To evaluate biodistribution of 89Zr-atezolizumab in patients with high risk DLBCL at diagnosis.Secondary objective:• To assess the heterogeneity of 89Zr-atezolizumab tumor uptake in high-risk DLBCL before R-CHOP.• To correlate…
Development of blood-based monitoring techniques for treatment response evaluation and diagnostics in lymphoid neoplasms, including HL and NHL by using extracellular vesicle and cfDNA techniques for biomarker discovery, assay development and…
To clarify the pathophysiological genetic pathway of the association between C. burnetii and NHL
The primary objective of this study is to determine the correlation between the 25-hydroxyvitamin D serum levels and PN in patients with multiple myeloma.