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Comparing the value of HPV transcript analysis and analysis of DNA methylation status for stratification of high-risk HPV positive women for risk of developing high grade cervical intraepithelial neoplasia (CIN) lesions and cervical carcinoma, to that of conventional cytology.

To compare the value of HPV transcript analysis and analysis of DNA methylation status with that of cytology examination as tools for stratification of hr-HPV positive women for risk of high-grade CIN lesions and cervical carcinoma (*CIN2). The aim…

A short CBT intervention for sexual rehabilitation among women receiving radiotherapy with gynecological cancer: A pilot study.

To investigate whether a short CBT intervention for sexual rehabilitation is feasible for patients (and their partners) and professionals. The available literature underscores the importance of sexual problems after pelvic RT and the need to develop…

MPAC-study: A feasibility study of the co-registration of MRI-imaging with PAthological assessment of primary tumor extension in patients with uterine Cervical tumors.

The objective of this study is to investigate the faesibility to fuse images of patholocial anatomy after uterusextirpation according to Wertheim-Okabayashi into tyhe pre-operative T2/DWI/DCE weighted MR images using non-rigid co-registration.

Phase IB-II, open label, multicentre feasibility study of pazopanib in combination with Paclitaxel and Carboplatin in patients with platinumrefractory/ resistant ovarian, fallopian tube or peritoneal carcinoma.

The primary objective of the phase IB part is to establish the maximum tolerated dose for pazopanib in combination with paclitaxel and carboplatin given weekly in a group of patients with platinum-refractory or -resistant ovarian, fallopian tube or…

Detection of loco-regional invasion of cervical cancer with 7 Tesla MRI

To develop and in vivo optimize T2w ultra high field (7T) MRI sequences, which use a combination of an endorectal and external coil, to image the (para)cervical area for assessment of the loco-regional tumor status in cervical cancer.

Feasibility of using the Pap-smear as a screening device for the detection of endometrial and ovarian cancer

To verify the feasibility of using the Pap-smear in diagnosing endometrial and ovarian cancer.

Nodal Metastasis in Endometrial Cancer: Detection Methods and Clinical Significance of lymph node micrometastasis

This study consists of two phases. For more information about the study layout, see page 13-16 of the research protcol.The aim of phase 2:- To compare two different sentinel node techniques in patients, suspicious for endometrial cancer. The main…

Pelvic versus peripheral steroid levels in postmenopausal patients with and without endometrial hyperplasia or carcinoma.

The aim of the study is to investigate the local levels of steroid-hormones compared to the peripheral levels in postmenopausal patients with endometrial hyperplasia, endometrial carcinoma and postmenopausal women without these diseases. This will…

p53 synthetic long peptides vaccine with cyclophosphamide for ovarian cancer, a phase II trial.

Primary objectives:- To improve the clinical effectiveness of the p53 synthetic long peptides vaccine by pre-administration of cyclophosphamide.- To evaluate the immunogenicity of a p53 synthetic long peptide vaccine when preceded by administration…

An open, prospective, comparative clinical trial to evaluate the improvement of the colposcopist with the use of DySIS* compared to conventional colposcopy.

Primary:To validate the latest version of DySIS in discriminating high grade (HG) from low grade (LG) lesions and non neoplastic tissue as well as in selecting the most atypical site for biopsy sampling, through digital documentation and…

A randomized, parallel group, open-label, active controlled, multicenter Phase III trial of Patupilone (EPO906) versus pegylated liposomal doxorubicin (Doxil/Caelyx) in taxane/platinum refractory/resistant patients with recurrent epithelial ovarian, primary fallopian or primary peritoneal cancer

To show superiority of patupilone in overall survival compared to pegylated liposomal doxorubicin (Doxil®/Caelyx®) in taxane/platinum refractory/resistant patients with recurrentovariancancer.

THE FITEC STUDY: Free Iron release during chemotherapy in Testicular Cancer Patients

Primary Objective:To identify suitable markers and their time course in order to better understand BEP chemotherapy induced oxidative stress in a minimally invasive manner.Secondary Objective:To measure the effect of chemotherapy on the elasticity…

The added value of MRI for detection of prostate cancer: validation with MR guided biopsies, fusion of MRI and transrectal ultrasound guided biopsies and TRUS guided biopsies.

To determine detection rates of MRGB comparing to TRUSGB and MR-US-Fusion-GB within patients who are at risk for prostate cancer but have no histological prove of prostate cancer, and who underwent at least one negative TRUSGBTo determine the…

Effects of irradiation on hypoxia and proliferation in cervical cancer and their potential predictive value; a pilot study

The objective is to determine if, and if so to what extend, there is a change in expressionpattern for hypoxic en proliferative markers.

A randomized controlled trial to evaluate the effect on pelvic floor function of pelvic physiotherapy following radical hysterectomy in early stage cervical cancer.

To find out whether pelvic physiotherapy added to an information folder describing pelvic exercises, as is the standard post-operative policy, gives an improved pelvic related quality of life compared to patients receiving the folder only.

Validation and evaluation of a gene set classifier for late radiation toxicity in prostate cancer patients

Prospective validation of a previously determined gene set expression classifier that allows assessment of late radiation toxicity risk in irradiated prostate cancer patients.

Identification of pre-malignancies found in the endometrium as possible precursor lesions of the serous papillary ovarian carcinoma in BRCA1 and/or BRCA2 mutation bearing women.

Identification of pre-malignancies found in the endometrium, obtained by dilatation & curettage, as possible precursor lesions of the serous papillary ovarian carcinoma.

Repeated CT study in patients with cervical cancer to assess organ motion for adaptive radiotherapy and proton therapy planning

To develop a strategy for online-adaptive radiotherapy with protons in patients with cervical cancer.

18F-FDG PET-MRI in patients with uterine cervical cancer - PETRA-C

Feasibility of 18F-FDG PET-MRI in inoperable uterine cervical cancer.

A phase III Trial of postoperative chemotherapy or no further treatment for patients with node-negative stage I-II intermediate or high risk endometrial cancer.

To demonstrate efficacy of adjuvant combination chemotherapy in a randomized phase III trial comparing to no further treatment in the medium and high-risk node negative stage I and stage II patients.