152 results
Objective: Evaluate uterine contraction features (frequency, amplitude, direction, and coordination) using a dedicated speckle-tracking algorithm by 2D transvaginal ultrasound measurement in postmenopausal women presenting with vaginal bleeding or…
Evaluate the antitumor activity of nemvaleukin alfa (*nemvaleukin*, ALKS 4230) in combination with pembrolizumab as compared with chemotherapy in patients with platinum-resistant ovarian cancerSecondary Objectives:Evaluate the antitumor activity of…
This study aims to investigate the progression-free survival (PFS) according to RECIST 1.1 criteria on matched targeted therapy by STA-analysis (PFS2) in comparison to the PFS recorded on the therapy administered immediately prior to enrolment (PFS1…
This study has been transitioned to CTIS with ID 2024-511966-36-00 check the CTIS register for the current data. To evaluate the bilateral SLN detection rate of intraoperative ICG with NIR fluorescence imaging compared to the current standard of…
Primary objectives:MoMaTEC2 aims to test the applicability of already identified and promising molecular biomarkers ER and PR, to improve risk stratification and individualisation of treatment for patients with EC.Secondary objectives:To perform a…
Primary Objectives- To evaluate disease related characteristics in patients with different vulvar conditions compared to healthy volunteers - To evaluate the variability of the selected biomarkers between subjects, and within subjects over time.…
This study has been transitioned to CTIS with ID 2024-516708-40-00 check the CTIS register for the current data. The primary objective of this proof-of-concept study is to evaluate feasibility of 68Ga-tilmanocept PET/CT for SLN mapping in patients…
The objective of this study is to follow up with females exposed to eleclazine in prior clinical trials.
This study has been transitioned to CTIS with ID 2024-512353-24-01 check the CTIS register for the current data. The primary objective of this study is to show immunological efficacy of autologous tumor-lysate loaded XP-DC in epithelial ovarian…
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
This study has been transitioned to CTIS with ID 2023-507230-24-00 check the CTIS register for the current data. To assess the feasibility of preserving fertility in women with 2018 FIGO stage IB2 cervical cancer with lesions measuring >2 cm…
In the RAINBO POLEmut-BLUE trial, omission of adjuvant therapy will be investigated in very low risk disease and de-escalation of treatment (observation or radiotherapy, but not chemoradiation) in low risk disease.
This study has been transitioned to CTIS with ID 2023-509049-11-00 check the CTIS register for the current data. The primary objective of this study is to evaluate the effect of HIPEC on overall survival when added to primary cytoreductive surgery…
The main objective of the SOPI study is to select the HRD test that best predicts longest PFS on PARP-i in non-BRCA1/2 EOC patients, in order to adequately select patients that will benefit from a PARP-i. Secondary objectives are: to evaluate the 1-…
This study has been transitioned to CTIS with ID 2024-514711-99-00 check the CTIS register for the current data. To evaluate BSA-based versus concentration-based OVHIPEC with cisplatin in patients with advanced-stage ovarian cancer.
We aim to study B cells derived from tumor and peripheral blood of uterine cancer patients in order to evaluate B cell-produced (tumor binding) antibodies for potential diagnostic and therapeutic interventions.
The primary objective of this study is to determine the immune-activating capacity of treatment with pembrolizumab and carboplatin/paclitaxel in the neo-adjuvant setting of primary stage IV ovarian cancer as measured by the alteration in magnitude…
The primary objective of this trial is to determine clinical efficacy of Vvax001 in CIN3 patients.
The primary objective of this study is to assess if clinically relevant changes occur in fat free mass (FFM) between baseline and follow up six months after the end of treatment. Our cut-off value of a clinically relevant difference in body…
1) What is the variation in follow-up care practice since 2011 for cervical cancer patients?2) What physician-, patient- and informal caregiver -factors are associated with differences in follow-up care schedules? Regarding patient/ informal…