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A phase IIIb, open, multi-centre gynaecological extension study for the follow-up of a subset of HPV-015 study subjects

To provide clinical management and, if required, treatment to subjects who at their concluding HPV-015 study visit displayed normal cervical cytology but tested positive for oncogenic HPV infection or who were pregnant at their concluding visit of…

A Randomized, Double-Blinded, Controlled with GARDASIL® (Human Papillomavirus Vaccine [Types 6, 11, 16, 18] (Recombinant, adsorbed)), Phase 3 Clinical Trial to Study the Immunogenicity and Tolerability of V503 (9-Valent Human Papillomavirus [HPV] L1 Virus-Like Particle [VLP] Vaccine) in 16- to 26-year-old men.

This study is designed to evaluate the immunogenicity and tolerability of V503 in young men, 16 to 26 years of age, in comparison to GARDASIL® in young men, 16 to 26 years of age. The safety and immunogenicity data will be used to bridge GARDASIL®…

A phase III, double-blind, randomized, controlled study to evaluate the safety, immunogenicity and efficacy of GlaxoSmithKline Biologicals* HPV 16/18 L1/AS04 vaccine administered intramuscularly according to a three-dose schedule (0, 1, 6 month) in healthy adult female subjects aged 26 years and above.

* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…

Comparing the value of HPV transcript analysis and analysis of DNA methylation status for stratification of high-risk HPV positive women for risk of developing high grade cervical intraepithelial neoplasia (CIN) lesions and cervical carcinoma, to that of conventional cytology.

To compare the value of HPV transcript analysis and analysis of DNA methylation status with that of cytology examination as tools for stratification of hr-HPV positive women for risk of high-grade CIN lesions and cervical carcinoma (*CIN2). The aim…

A short CBT intervention for sexual rehabilitation among women receiving radiotherapy with gynecological cancer: A pilot study.

To investigate whether a short CBT intervention for sexual rehabilitation is feasible for patients (and their partners) and professionals. The available literature underscores the importance of sexual problems after pelvic RT and the need to develop…

A randomized controlled trial to evaluate the effect on pelvic floor function of pelvic physiotherapy following radical hysterectomy in early stage cervical cancer.

To find out whether pelvic physiotherapy added to an information folder describing pelvic exercises, as is the standard post-operative policy, gives an improved pelvic related quality of life compared to patients receiving the folder only.

Adjuvant vaccination against HPV in surgical treatment of CIN lesions, a Randomised Controlled Trial.

Evaluate the efficacy of nonavalent HPV vaccination in women with a CIN lesion who will undergo or have undergone a LEEP in preventing recurrent CIN II-III after 24 months.

FOllow-up among Cervical cancer sUrvivorS, perspectives from survivors, informal caregivers and health care providers (FOCUS): a cross-sectional population-based study

1) What is the variation in follow-up care practice since 2011 for cervical cancer patients?2) What physician-, patient- and informal caregiver -factors are associated with differences in follow-up care schedules? Regarding patient/ informal…

Early TUbectomy with delayed oophorectomy to improve quality of life as alternative for risk reducing salpingo-oophorectomy in BRCA1/2 gene mutation carriers

To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…