19 results
To provide clinical management and, if required, treatment to subjects who at their concluding HPV-015 study visit displayed normal cervical cytology but tested positive for oncogenic HPV infection or who were pregnant at their concluding visit of…
Determine which anaesthetic technique (general anaesthesia in combination with TAP blockade versus general anaesthesia in combination with thoracic epidural analgesia)offers the most benefits, with respect to attenuation of the surgical inflammatory…
The aim of the present study is to identify aberrations that play a significant role in therapy response of ovarian cancer patients. RNA sequence/expression and protein expression data will be combined and correlated to the extensive clinical follow…
This study is designed to evaluate the immunogenicity and tolerability of V503 in young men, 16 to 26 years of age, in comparison to GARDASIL® in young men, 16 to 26 years of age. The safety and immunogenicity data will be used to bridge GARDASIL®…
* To demonstrate efficacy of the candidate vaccine in the prevention of (1) persistent infection (6-month definition) with HPV-16 or HPV-18 (by polymerase chain reaction [PCR]) and/or (2) histopathologically-confirmed CIN1+ associated with HPV-16 or…
To compare the value of HPV transcript analysis and analysis of DNA methylation status with that of cytology examination as tools for stratification of hr-HPV positive women for risk of high-grade CIN lesions and cervical carcinoma (*CIN2). The aim…
The aim of the study is to investigate the local levels of steroid-hormones compared to the peripheral levels in postmenopausal patients with endometrial hyperplasia, endometrial carcinoma and postmenopausal women without these diseases. This will…
Primary:To validate the latest version of DySIS in discriminating high grade (HG) from low grade (LG) lesions and non neoplastic tissue as well as in selecting the most atypical site for biopsy sampling, through digital documentation and…
To find out whether pelvic physiotherapy added to an information folder describing pelvic exercises, as is the standard post-operative policy, gives an improved pelvic related quality of life compared to patients receiving the folder only.
Identification of pre-malignancies found in the endometrium, obtained by dilatation & curettage, as possible precursor lesions of the serous papillary ovarian carcinoma.
The purpose of this study is to investigate the characteristics of different sub cellular constituents in different body fluids of patients with advanced EOC with different histotypes. Besides obtaining more clarity about the role of these…
The aim of this study is to investigate the structure and the biological behaviour of the peritoneum, in relation to the specific growth of EOC on the peritoneum, in order to identify the component of the peritoneum that maintains the blood-belly-…
Objective: Evaluate uterine contraction features (frequency, amplitude, direction, and coordination) using a dedicated speckle-tracking algorithm by 2D transvaginal ultrasound measurement in postmenopausal women presenting with vaginal bleeding or…
Primary objective:To identify common mutations or other genetic alterations and their potential as therapeutic targets in granulosa cell tumours, by studying human granulosa cell tumour specimens and establishing 3D organoid cell cultures derived…
Evaluate the efficacy of nonavalent HPV vaccination in women with a CIN lesion who will undergo or have undergone a LEEP in preventing recurrent CIN II-III after 24 months.
We expect the BMI and the type of fat distribution to have a significant influence on the change in hormone levels, fat metabolism and systemic inflammation levels after bilateral salpingo-oophorectomy (BSO). In patients with endometrial cancer,…
1. What is the level of psychological distress among cervical cancer patients over time?2. What is the role of characteristics of the individual, characteristics of the environment, biological function, overall quality of life, functional status and…
To evaluate RRS after childbearing with delayed RRO as an alternative for RRSO in BRCA1/2 gene germline mutation carriers. We hypothesize that delay of menopause leads to an improvement of quality of life and sexual functioning, and a decrease in…
To assess the potential of [18F]FB-IL2 PET to detect the infiltration of IL2 receptor (IL2R) positive immune cells in cervical cancer tissue during radiochemotherapy treatment using IL2 receptor positive cells in tumor biopsies as (golden standard).